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Fig. 1 | Respiratory Research

Fig. 1

From: Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Fig. 1

Experimental Design. a CF cells (IB3–1) are treated with small molecule therapies. Tests are for consequences on IκBα and NFκB signaling, chemokine and cytokine secretion, and functional interactions among drugs. b IB3–1 and AAV[WT]CFTR gene therapy (S9) cell transcriptomes are profiled with RNA-seq. Tests are for proinflammatory gene expression, drug effects on gene expression, and parallels between drugs and gene therapy. c Recent CF patient gene expression data is compared with in vitro data. Tests are based on re-analysis of Affymetrix microarray mRNA data from nasal epithelial biopsies of CF patients, followed by comparisons with CF cell RNA-seq data

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