Improved hemodynamics and cardiopulmonary function in patients with inoperable chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty

Jin, Qi; Luo, Qin; Yang, Tao; Zeng, Qixian; Yu, Xue; Yan, Lu; Zhang, Yi; Zhao, Qing; Ma, Xiuping; An, Chenhong; Xiong, Changming; Zhao, Zhihui; Liu, Zhihong

doi:10.1186/s12931-019-1211-y

Table 2 Hemodynamics and clinical parameters before and after a single BPA session and multiple BPA sessions

From: Improved hemodynamics and cardiopulmonary function in patients with inoperable chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty

Parameters	Single BPA session (n = 40)			Multiple BPA sessions (n = 10)
Parameters	Pre-BPA	Post-BPA	P value	Before-first BPA	After-last BPA	P value
RHC
SvO₂, %	69.8 ± 5.1	–		68.14 ± 4.43	72.07 ± 2.97^a	0.019
SaO₂, %	91.4 ± 2.1	91.9 ± 2.7	0.262	90.2 ± 1.8	91.9 ± 1.6^a	0.01
mRAP, mmHg	7.4 ± 2.9	–		7.3 ± 3.9	8.1 ± 2.5^a	0.54
sPAP, mmHg	84.4 ± 22.8	74.7 ± 21.9	< 0.001	93.0 ± 26.0	81.2 ± 18.7^a	0.068
dPAP, mmHg	29.4 ± 7.8	25.5 ± 7.3	< 0.001	31.9 ± 9.0	27.8 ± 4.3^a	0.089
mPAP, mmHg	47.4 ± 11.9	41.5 ± 10.7	< 0.001	52.6 ± 14.1	44.8 ± 8.2^a	0.031
PVR, dyne·s·cm⁻⁵	886.15 ± 342.04	–		1067.0 ± 410.4	758.0 ± 212.1^a	0.04
PAWP, mmHg	9.8 ± 3.2	–		8.1 ± 2.8	10.7 ± 3.0^a	0.164
CI, l/min/m²	3.26 ± 0.78	–		3.07 ± 0.69	3.42 ± 0.70^a	0.202
TTE
LVED, mm	41.1 ± 4.9	42.0 ± 5.1	0.203	41.4 ± 3.7	43.7 ± 3.8	0.048
RVED, mm	31.3 ± 7.4	30.2 ± 6.4	0.142	30.5 ± 4.0	28.1 ± 5.1	0.32
TAPSE, mm	16.5 ± 4.2	17.2 ± 3.5	0.296	16.2 ± 4.2	18.3 ± 1.5	0.304
Pulmonary function testing
FVC, l	3.11 ± 0.83	3.21 ± 0.93	0.037	3.22 ± 0.84	3.49 ± 1.01	0.01
FVC% predicted, %	90.7 ± 13.0	93.4 ± 14.5	0.041	95.8 ± 12.0	103.6 ± 11.2	0.004
FEV1, l	2.26 ± 0.64	2.32 ± 0.71	0.034	2.39 ± 0.69	2.55 ± 0.79	0.023
FEV1% predicted, %	80.8 ± 14.2	82.7 ± 16.1	0.045	87.9 ± 16.5	93.2 ± 15.4	0.038
MVV, l/min	89.4 ± 31.7	99.1 ± 34.7	< 0.001	95.2 ± 37.7	114.1 ± 36.2	0.002
MVV% predicted, %	83.2 ± 24.0	92.4 ± 25.2	< 0.001	89.0 ± 26.4	108.4 ± 26.0	0.005
NT-proBNP, pg/ml	1161.8 ± 1420.0	671.2 ± 753.0	0.001	1329.0 ± 1599.0	326.5 ± 601.0	0.022
6MWD, m	350.0 ± 103.4	403.6 ± 81.3	< 0.001	316.8 ± 120.2	443.9 ± 63.6	0.003
WHO-FC I/II/III/IV	2.3 ± 0.5	1.9 ± 0.5	< 0.001	2.7 ± 0.5	2.0 ± 0	0.001
I, n (%)	1 (2.5%)	8 (20%)		0 (0%)	0 (0%)
II, n (%)	26 (65%)	30 (75%)		3 (30%)	10 (100%)
III, n (%)	13 (32.5%)	2 (5%)		7 (70%)	0 (0%)
IV, n (%)	0 (0%)	0 (0%)		0 (0%)	0 (0%)

BPA balloon pulmonary angioplasty, RHC right heart catheterization, SvO₂ mixed venous oxygen saturation, SaO₂ arterial oxygen saturation, mRAP mean right atrial pressure, sPAP systolic pulmonary artery pressure, dPAP diastolic pulmonary artery pressure, mPAP mean pulmonary artery pressure, PVR pulmonary vascular resistance, PAWP pulmonary arterial wedge pressure, CI cardiac index, TTE transthoracic echocardiography, LVED left ventricular end-diastolic diameter, RVED right ventricular end-diastolic diameter, TAPSE tricuspid annular plane systolic excursion, FVC forced vital capacity, FEV1 forced expiratory volume in the first second, MVV maximal voluntary ventilation, NT-proBNP N-terminal pro-brain natriuretic peptide, 6MWD 6-min walk distance, WHO-FC WHO functional class
^aData at RHC before the last BPA

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com

Respiratory Research

Contact us