Table 1 Partial Current Literature on BALF-EVs in Lung Diseases
Diseases/processes | Main conclusion | Author/Journal |
|---|---|---|
Idiopathic Pulmonary Fibrosis (IPF) | Increased BALF-EVs function as carriers for WNT5A, and contribute to the pathogenesis of IPF | Martin-Medina et al.; AJRCCM 2018, Jul 25. |
Asthma/COPD Bronchoconstriction | Mediate leukotriene conversion LTC4-LTD4 | Lukic et al.; J Lipid Res 2016; 57:1659–69 |
Allergic Asthma | Leukotriene/cytokine production | Torregrosa Paredes et al.; Allergy. 2012 Jul;67(7):911–9 |
Allergy and vaccination | EVs can potentially induce tolerance | Prado et al.; J. Immunology 2008. 181 |
Asthma | EV-lipid profile as a biomarker | Hough et al.; Sci Report, 2018 10,340 |
COPD | EVs from PMN regulate the pathogenesis | Genschmer et al. Cell. 2019 Jan 10 |
Sarcoidosis | BALF EVs from sarcoidosis patients carry pro-inflammatory effects. | Qazi et al.; Thorax, 2010; 65 |
Lung transplant Acute rejection | The BALF EV profiles are altered in patients with acute rejection | Gregson et al.; AJRCCM 2015, Dec.15 |
Lung Cancer | BALF EVs contribute to lung cancer growth | Yang et al.: Frontier in Oncology 2019; April 12 |
Early stage Lung Ca | BALF EVs as a diagnostic marker | Kim et al.: Chest 2016 Oct Vol 150–4 |
Lung Cancer | Biomarker of cancer growth | Yang et al |
ARDS | BALF-EV-miRNAs mediate inflammation and ALI | Sheller et al.: J Infectious Dis. 2019. Jan. 19th |
Lung Injury | BALF-EV-miRNAs mediate sterile stimuli-associated ALI. | Lee et al.: J Immunology 2018 |
Pneumonia/sepsis | Macrophage-derived EVs regulate inflammation. | Soni et al. Thorax.2016 June 10 |
Pulmonary Hypertension | Exosomal 15-LO2 mediates hypoxia-mediated HTN | Zhang et al. Cell Death Dis. 2018 Oct 3;9(10):1022 |