Fig. 5

Down-regulated lncRNA SNHG14 prevents LPS-induced ALI via miR-34c-3p-mediated WISP1 inhibition in vivo. A, the representative micrographs showing lung tissue morphological changes after HE staining (400 ×), n = 10. B, the levels of IL-18, IL-1, TNF-α, and IL-6 in bronchoalveolar lavage fluid measured by ELISA, n = 10. C, representative images showing pathological changes in lung tissues from ALI mice injected with adenoviruses harboring different plasmids observed after HE staining (400 ×), n = 10. D, lung injury score of ALI mice injected with adenoviruses harboring different plasmids. E, the neutrophils in the BALF of ALI mice injected with adenoviruses harboring different plasmids. F, MPO activity in ALI mice injected with adenoviruses harboring different plasmids. G, pulmonary edema evaluated by determining wet/dry weight ratio in ALI mice injected with adenoviruses harboring different plasmids, n = 10. * p < 0.05 vs. the NC-ASO + oe-NC group, # p < 0.05 vs. the SNHG14-ASO + oe-NC group, & p < 0.05 vs. the NC mimic + oe-NC group, @ p < 0.05 vs. the miR-34c-3p mimic + oe-NC group. The statistical values were measurement data and expressed as mean ± standard deviation. Comparisons were analyzed using one-way ANOVA. The experiment was repeated 3 times independently