Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens

Respiratory Research

Table 1 Production of IL-8 and TNF- α following treatment of A549 cells with pathway inhibitors, and infection with bacteria, or bacteria exposed to cigarette smoke extract or electronic cigarette vapour. Where a statistically significant reduction in cytokine was observed, this was denoted by “↓”

	Significant decrease (↓)in IL-8 following treatment of A549 cells with pathway inhibitors, and infection with bacteria +/− CSE or ECVE				Significant decrease (↓)in TNF-α following treatment of A549 cells with pathway inhibitors, and infection with bacteria +/− CSE or ECVE
	NFκB inhibitor (BAY117085)	MAPK inhibitor (SB203580)	JNK inhibitor (SP600125)	MEK1/2 inhibitor (U0126)	NFκB inhibitor (BAY117085)	MAPK inhibitor (SB203580)	JNK inhibitor (SP600125)	MEK1/2 inhibitor (U0126)
H. influenzae		↓		↓	↓	↓
H. influenzae + CSE		↓		↓	↓	↓
H. influenzae + ECVE		↓		↓	↓	↓
S. pneumoniae		↓		↓		↓	↓
S. pneumoniae + CSE				↓		↓	↓
S. pneumoniae + ECVE		↓				↓	↓
S.aureus	↓		↓	↓	↓			↓
S.aureus + CSE	↓		↓		↓			↓
S.aureus + ECVE	↓		↓	↓	↓			↓
P.aeruginosa	↓	↓	↓	↓			↓	↓
P.aeruginosa + CSE	↓	↓	↓	↓		↓	↓	↓
P.aeruginosa + ECVE	↓	↓	↓	↓			↓	↓

ISSN: 1465-993X