Fig. 1
From: Chemical pleurodesis – a review of mechanisms involved in pleural space obliteration
The role of inflammation in pleurodesis. In brief, inflammation is the most common mechanism involved in pleurodesis. Mesothelial cells which are directly exposed to the sclerosing agent initiate the chain of inflammatory reactions by secretion of a variety of mediators. These include the influx of neutrophils induced by interleukin 8 (IL-8) produced by mesothelial cells; see text for details. Solid lines represent stimulation; *- see also the role of matrix metalloproteinases (MMPs) in Fig. 3. Please, note that the figure is a simplified diagram summarizing the inflammatory mechanisms involved in pleurodesis. The actual mechanisms are probably far more complex