Fig. 7

a Compared with the exosome mRNA obtained from BALF with that from plasma, it was found that almost all mRNAs were equally expressed in two types of body fluids, including MET. b In comparing icotinib effectivity in a patient’s plasma exo-mRNA with icotinib-resistant patients, it was found that exo-MET was specifically expressed in icotinib-resistant patients. The CT scan revealed the different processes of the disease after icotinib treatment. c The sensitivity and specificity of score of formula through the ROC curve: AUC = 0.98, P = 0,012, Cut-off value 1 = − 0.7526, and cut-off value 2 = − 0.45115. d The formula log₁₀2^{Score 2nd-Score 1st} was used to calculate the relationship between the 10 candidates’ exo-mRNAs and the disease progression by PFS. (median of high score was 4, P = 0.0399)