Skip to main content
Fig. 4 | Respiratory Research

Fig. 4

From: Icotinib-resistant HCC827 cells produce exosomes with mRNA MET oncogenes and mediate the migration and invasion of NSCLC

Fig. 4

The role of HCC827IR-derived exosomes on HCC827 cells and MET was specifically expressed in IR exosomes. a MTT assay of HCC827 cells with icotinib treatment at different concentrations for 48 h after treatment with HCC827IR cells and icotinib-resistant exosomes. b The expression of the cell cycle and cell cycle arrest-related mRNA (CDk2, CDk4, CDKN1a and CDKN1B) in HCC827 and HCC827 co-cultured with icotinib-resistant exosomes was assessed by qRT-PCR. c The Transwell assay was performed to determine the invasion and migration ability of HCC827 cells after treatment with EDS, icotinib-resistant exosomes, and icotinib-resistant MET−/− exo. The migration and invasion cell numbers were analyzed by t-test. d The MET expression in HCC827IR exosomes was detected by PCR analysis and gel electrophoresis

Back to article page