Fig. 3

The absolute difference in risk of NV in DMD patients stratified by ADRB2 genotype. The risk curve is representative of the absolute difference in the cumulative risk for each genotype. The cumulative risks for each genotype was obtained from the Cox regression modeling of the risk of nocturnal ventilation where genotype group, patient age at entry into the study, ambulatory status, corticosteroid-use, weight, and FVC were entered into the model as covariates. The reference lines denote the absolute difference in risk between genotype variants at the ages of 22 and 27 years of age. Note that the difference in risk of NV between Arg16 and Gly16 genotype groups is marginal (< 1%) at ages below 22, yet widens greatly to over 25% by the age of 27 years