Table 1 Demographic and clinical characteristics of new and relapse TB patients, Shandong, China, 2004–2018a
From: Primary drug resistance of mycobacterium tuberculosis in Shandong, China, 2004–2018
Characteristics | New case,no.,(%) n = 11,467 | Relapse case,no.,(%) n = 1981 | New case vs Relapse case (control) | Primary DR-TB vs Acquired DR-TB | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total n = 11,467 | DR-TB n = 2173 | Susceptible TB n = 9294 | OR (95% CI) | P value | Total n = 1981 | DR-TB n = 505 | Susceptible TB n = 1476 | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
Age (years) | ||||||||||||||
0–14 | 26(0.23) | 5(0.23) | 21(0.23) | – | – | 4(0.20) | 1(0.20) | 3(0.20) | – | – | – | – | – | – |
15–44 | 4796(41.82) | 930(42.80) | 3866(41.60) | Ref. | Ref. | 719(36.29) | 191(37.82) | 528(35.77) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
45–64 | 3655(31.87) | 728(33.50) | 2927(31.49) | 1.034(0.928–1.152) | 0.546 | 652(32.91) | 182(36.04) | 470(31.84) | 1.070(0.844–1.358) | 0.575 | 0.840(0.750–0.942) | 0.003 | 0.822(0.656–1.029) | 0.087 |
> 65 | 2890(25.20) | 486(22.37) | 2404(25.87) | 0.840(0.745–0.948) | 0.005 | 509(25.69) | 101(20.00) | 408(27.64) | 0.684(0.521–0.900) | 0.007 | 0.851(0.753–0.962) | 0.010 | 0.988(0.758–1.288) | 0.930 |
Sex | ||||||||||||||
Female | 2153(18.78) | 368(16.94) | 1785(19.21) | Ref. | Ref. | 357(18.02) | 82(16.24) | 275(18.63) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Male | 9311(81.20) | 1805(83.06) | 7506(80.76) | 1.166(1.031–1.32) | 0.014 | 1556(78.55) | 402(79.60) | 1154(78.18) | 1.168(0.891–1.533) | 0.262 | 0.992(0.876–1.123) | 0.902 | 1.001(0.769–1.301) | 0.997 |
Cavity | ||||||||||||||
No | 6214(54.19) | 1142(52.55) | 5072(54.57) | Ref. | Ref. | 1156(58.35) | 251(49.70) | 905(61.31) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Yes | 3854(33.61) | 758(34.88) | 3096(33.31) | 1.087(0.982–1.204) | 0.108 | 637(32.16) | 191(37.82) | 446(30.22) | 1.544(1.240–1.924) | P < 0.001 | 1.126(1.024–1.250) | 0.027 | 0.872(0.707–1.075) | 0.201 |
Unknown | 1399(12.20) | 273(12.56) | 1126(12.12) | 1.077(0.930–1.247) | 0.324 | 188(9.49) | 63(12.48) | 125(8.47) | 1.817(1.302–2.537) | P < 0.001 | 1.384(1.174–1.632) | P < 0.001 | 0.952(0.701–1.294) | 0.755 |
Smoking | ||||||||||||||
No | 4809(41.94) | 885(40.73) | 3924(42.22) | Ref. | Ref. | 1507(76.07) | 358(70.89) | 1149(77.85) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Yes | 1660(14.48) | 302(13.90) | 1358(14.61) | 0.986(0.853–1.139) | 0.849 | 371(18.73) | 105(20.79) | 266(18.02) | 1.267(0.982–1.635) | 0.069 | 1.402(1.235–1.591) | P < 0.001 | 1.163(0.903–1.5) | 0.242 |
Unknown | 4998(43.59) | 986(45.38) | 4012(43.17) | 1.057(0.955–1.169) | 0.288 | 103(5.20) | 42(8.32) | 61(4.13) | 2.210(1.466–3.331) | P < 0.001 | 15.206(12.406–18.638) | P < 0.001 | 9.497(6.812–13.24) | P < 0.001 |
Drinking | ||||||||||||||
No | 5032(43.88) | 931(42.84) | 4101(44.13) | Ref. | Ref. | 1552(78.34) | 381(75.45) | 1171(79.34) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Yes | 1398(12.19) | 250(11.5) | 1148(12.35) | 0.959(0.822–1.119) | 0.597 | 315(15.90) | 79(15.64) | 236(15.99) | 1.029(0.778–1.361) | 0.842 | 1.369(1.196–1.566) | P < 0.001 | 1.295(0.979–1.713) | 0.070 |
Unknown | 5037(43.93) | 992(45.65) | 4045(43.52) | 1.080(0.978–1.193) | 0.128 | 114(5.75) | 45(8.91) | 69(4.67) | 2.004(1.353–2.969) | 0.001 | 13.628(11.233–16.548) | P < 0.001 | 9.021(6.540–12.444) | P < 0.001 |
Type | ||||||||||||||
Extrapulmonary TB | 40(0.35) | 7(0.32) | 33(0.36) | Ref. | Ref. | 17(0.86) | 7(1.39) | 10(0.68) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Pulmonary TB | 11,427(99.65) | 2166(99.68) | 9261(99.64) | 1.103(0.484–2.496) | 0.815 | 1964(99.14) | 498(98.61) | 1466(99.32) | 0.485(0.184–1.282) | 0.145 | 2.473(1.399–4.370) | 0.002 | 4.349(1.519–12.456) | 0.006 |