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Table 1 Patient and healthy subject characteristics

From: Enhanced Bruton’s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

  Blood Lung MLN
HC (n = 21) IPF (n = 27) Control (n = 9) IPF (n = 11) Control (n = 13) IPF (n = 10)
Age, years (95% CI) 56 (52–61) 70 (67–73) 50 (56–66) 59 (55–63) 59 (56–61) 58 (53–61)
Gender: M/F (n, (%)) 12 (57%) /9 19 (70%)/8 5 (55%)/4 9 (81%)/2 8 (62%)/5 9 (90%)/1
Diagnosis
 -MDD: IPF/Prob IPF/Pos IPF(n, (%))   22 (81%)/5/0   11 (100%)/0/0   10 (100%)/0/0
 PA obtained (%)   22   100   100
History
 -Cardiovascular disease (n, (%))* 0 14 (51%) 3 (33%) 2 (18%)   2 (20%)
 -Auto-immune disease (n, (%))# 0 1 (3%) 1 (11%) 0 (0%)   0 (0%)
PFT, percentage predicted (95% CI)
 -TLCO   47 (42–53) 86 (76–95) 33 (27–39)   34 (27–40)
 -FVC   77 (72–83) 108 (95–121) 53 (45–60)   52 (44–60)
 -FEV1/FVC    69 (63–73)    
COPD (n) (stage)   0 3 (all GOLD1) 0   0
Smoking, n (%)
 -never   5 (19%) 2 (22%) 2 (18%)   2 (20%)
 -former   22 (81%) 7 (78%) 9 (82%)   8 (80%)
 -current   0 (0%) 0 (0%) 0 (0%)   0 (0%)
Medication
 -prednisone use: (n, (%))   8 (30%) 0 (0%) 4 (36%)   3 (30%)
dose (mg/day)       
  > 10 mg/d   0 (0%)   1 (9%)   0 (0%)
 </= 10 mg/d   8 (30%)   3 (27%)   3 (30%)
pa Other immunosuppressive (n, (%))   0 (0%) 0 (0%) 0 (0%)   0 (0%)
PO Please Pirfenidone (n, (%))   0 (0%)   2 (18%)   2 (20%)
 Nintedanib (n, (%))   1 (3%)   3 (27%)   3 (30%)
  1. * IPF patients (blood): Hypertension (n = 9), ischemic cardiac disease (n = 5), or transient ischemic attack (n = 2), Control lung: Hypertension (n = 3), Cerebro Vasculair Accident (n = 2)
  2. IPF lung and LN: Hypertension and transient ischemic attack (n = 1), Hypertension (n = 1)
  3. # IPF patients (blood): colitis ulcerosa (not active and no immunomodulating medication) (n = 1)
  4. Control lung: Rheumatoid arthritis (not active and no immunomodulating medication) without lung involvement or anti-CCP antibodies (n = 1)
  5. Abbreviations: MLN = mediastinal lymph node, MDD = multidisciplinary diagnosis, PFT = pulmonary function test, TLCO = carbon monoxide transfer factor, FVC = forced vital capacity, FEV1 = forced expiratory volume in one 1 s