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Fig. 4 | Respiratory Research

Fig. 4

From: Enhanced Bruton’s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

Fig. 4

More activated follicular helper T-cells (Tfh) in IPF lungs. (a) Representative gating strategy for identification of Tfh (CXCR5+CD45RACD4+) and activated Tfh (CXCR5+CD45RACD4+PD-1HI) as depicted for a representative blood and lung single cell suspension for a control and IPF patient. (b) Representative histogram overlay showing PD-1 expression levels of Tfh-cells depicted as MFI for a blood sample of an IPF patient (gray), control lung (blue) and IPF lung (red). (c) Activated Tfh-cells as percentage of total Tfh-cells in single cell suspensions of control lungs (n = 8) and IPF lungs (n = 11). Non-parametric two-tailed Mann-Whitney test was used. Data are expressed as mean and dots represent individual patient values. ** P < 0.01

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