Skip to main content
Fig. 1 | Respiratory Research

Fig. 1

From: Enhanced Bruton’s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

Fig. 1

Alterations in B-cell subsets in blood, LN and lungs of IPF patients. ((a) Representative gating strategy for identification of B-cell subsets in blood and single cell suspensions of lungs. Naïve B-cells (CD19+IgD+CD27-) IgD+ and IgD memory CD27+ B-cells, double negative (DN) B-cells (CD19+IgDCD27), transitional B-cells (CD19+CD24+CD38+), and plasmablast (CD19+CD38+CD27+) were identified. (b) c Percentage of circulating B-cell subsets of total B cells in HC (n = 21) and IPF patients (n = 27). (c) Proportion of B-cell subsets of total B-cells in single cell suspensions of control lungs (n = 9) and explanted IPF lungs (n = 11). Non-parametric two-tailed Mann-Whitney test was used. Data are expressed as mean and dots represent individual patient values. * P < 0.05 ** P < 0.01 *** P < 0.001

Back to article page