Fig. 6
From: Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines
Restored P53 function reverse MLN8237 resistance. a P53 induction in H460 and HCC2429 cells post 48 h MLN8237, radiation or combined treatment. b Cell survival after MLN8237 treatment when P53 was induced in H1299 cells by Doxycycline. T-test, ** p < 0.01. c DNA damage signaling after MLN8237, radiation, and combined treatment in H1299 cells with restored P53 function. Markable P53 and P21 can be induced by AURKA inhibition or radiation alone or combined