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Fig. 3 | Respiratory Research

Fig. 3

From: Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines

Fig. 3

MLN8237 induces programmed cell death and cell senescence. a Morphological change after MLN8237 treatment. The length of white bar represents the major axis of cancer cell. The dying cell was marked by arrow filled with black. A549 cell was using as representative cell senescence after treatment. b Feret’s diameter ratio of cells shown characteristics of cell senescence. Cell Feret’s diameter was calculated by ImageJ and averaged from 6 cells per image. Bar means mean ± SD, * p < 0.05, ** p < 0.01. c Cell fates distribution after MLN8237 treatment. Green bar means portion of living cells, red bar means portion of dead cells, blue means portion of senescent cells, Data showed as mean ± SD, * p < 0.05, ** p < 0.01. d MLN8237 induces apoptosis and DNA damage signaling in NSCLC cell lines. Cells were treated with increasing concentrations of MLN8237 for 48 h. Caspase-3 antibody recognizes both the full-length and cleaved fragment, PARP1 recognizes both the full-length and cleaved fragments

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