Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry

Table 3 Nine proteins that optimally differentiated patients with IPF from control participants. Proteins selected by the linear discriminant function with recursive feature elimination and the respective model coefficient

Gene	Aptamer ID	Protein	Model coefficient^a
APOA1	2750–3	Apolipoprotein A-I	0.38
C1R	3285–23	Complement C1r subcomponent	−0.41
MMP3	2788–55	Stromelysin-1	−0.30
SFN	4829–43	14–3-3 protein sigma	0.43
CCL18	3044–3	C-C motif chemokine 18	0.36
ICAM5	5124–69	Intercellular adhesion molecule 5	−0.06
SHH	2743–5	Sonic hedgehog protein	0.46
OLR1	3636–37	Oxidised low-density ipoprotein receptor 1	−0.32
CAPG	4968–50	Macrophage-capping protein	0.28

^aThe sign of the coefficient indicates whether the subject’s linear discriminant analysis score increases or decreases as values of the protein change. Higher scores are associated with IPF, as opposed to control, status

ISSN: 1465-993X