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Table 1 Baseline patient characteristics

From: Association of time-to-treatment with outcomes of Pneumocystis pneumonia with respiratory failure in HIV-negative patients

Characteristics

No. of patients (%) or median (IQR)

Age, years

52.0 (40.5–66.0)

Sex, male

35 (68.6)

Underlying disease

 Malignancy

28 (54.9)

  Hematologic

21

  Solid

7

 Solid organ transplant

18 (35.3)

  Kidney

11

  Liver

4

  Heart

2

  Lung

1

 Othera

5 (9.8)

Immunosuppressive agents used, previous monthb

 Steroid only

18 (35.3)

 Chemotherapy only

29 (56.9)

 Steroid with chemotherapy

4 (7.8)

Prednisolone-equivalent dose, mg, if steroid used

16.1 (6.2–34.7)

Pneumocystis prophylaxis

2 (3.9)

Chest radiography findings

 Pleural effusion

11 (21.6)

 Radiographic pulmonary pattern

  Focal or diffuse alveolar pattern

24 (47.1)

  Focal or diffuse interstitial pattern

5 (9.8)

  Focal or diffuse alveolar-interstitial pattern

22 (43.1)

Laboratory findings on ICU admission

 WBC blood cells,/μL

7960.0 (5320.0–12,225.0)

  Neutrophils,/μL

5458.0 (3245.0–10,395.0)

  Lymphocytes,/μL

580.0 (324.0–1020.0)

 Albumin, g/dL

2.8 (2.4–3.3)

 CRP, mg/dL

12.4 (8.2–19.6)

 PaO2/FiO2 ratio, mmHg

137.2 (112.8–164.6)

 D(A-a)O2, mmHg

39.9 (30.8–52.3)

Organ failure

 Shock

12 (23.5)

 Renal failure requiring renal replacement therapy

1 (2.0)

Respiratory support on ICU admission day

 Mechanical ventilation

43 (84.3)

 High-flow nasal cannula

8 (15.7)

Severity of illness

 SAPS 3

48.0 (37.0–57.5)

 SOFA

6.0 (5.0–8.0)

  1. No. number, IQR interquartile range, ICU intensive care unit, WBC white blood cell, CRP C-reactive protein, PaO2/FiO2 arterial partial pressure of oxygen/fraction of inspired oxygen, D(A-a)O2 alveolar-arterial oxygen gradient, SAPS 3 Simplified Acute Physiology Score 3, SOFA Sequential Organ Failure Assessment
  2. aOthers include 2 glomerulonephritis, 2 interstitial lung disease, and 1 liver cirrhosis
  3. bChemotherapy includes 4 patients with T-cell immunosuppressant