Association of time-to-treatment with outcomes of Pneumocystis pneumonia with respiratory failure in HIV-negative patients

Table 1 Baseline patient characteristics

Characteristics	No. of patients (%) or median (IQR)
Age, years	52.0 (40.5–66.0)
Sex, male	35 (68.6)
Underlying disease
Malignancy	28 (54.9)
Hematologic	21
Solid	7
Solid organ transplant	18 (35.3)
Kidney	11
Liver	4
Heart	2
Lung	1
Other^a	5 (9.8)
Immunosuppressive agents used, previous month^b
Steroid only	18 (35.3)
Chemotherapy only	29 (56.9)
Steroid with chemotherapy	4 (7.8)
Prednisolone-equivalent dose, mg, if steroid used	16.1 (6.2–34.7)
Pneumocystis prophylaxis	2 (3.9)
Chest radiography findings
Pleural effusion	11 (21.6)
Radiographic pulmonary pattern
Focal or diffuse alveolar pattern	24 (47.1)
Focal or diffuse interstitial pattern	5 (9.8)
Focal or diffuse alveolar-interstitial pattern	22 (43.1)
Laboratory findings on ICU admission
WBC blood cells,/μL	7960.0 (5320.0–12,225.0)
Neutrophils,/μL	5458.0 (3245.0–10,395.0)
Lymphocytes,/μL	580.0 (324.0–1020.0)
Albumin, g/dL	2.8 (2.4–3.3)
CRP, mg/dL	12.4 (8.2–19.6)
PaO₂/FiO₂ ratio, mmHg	137.2 (112.8–164.6)
D(A-a)O₂, mmHg	39.9 (30.8–52.3)
Organ failure
Shock	12 (23.5)
Renal failure requiring renal replacement therapy	1 (2.0)
Respiratory support on ICU admission day
Mechanical ventilation	43 (84.3)
High-flow nasal cannula	8 (15.7)
Severity of illness
SAPS 3	48.0 (37.0–57.5)
SOFA	6.0 (5.0–8.0)

No. number, IQR interquartile range, ICU intensive care unit, WBC white blood cell, CRP C-reactive protein, PaO₂/FiO₂ arterial partial pressure of oxygen/fraction of inspired oxygen, D(A-a)O₂ alveolar-arterial oxygen gradient, SAPS 3 Simplified Acute Physiology Score 3, SOFA Sequential Organ Failure Assessment
^aOthers include 2 glomerulonephritis, 2 interstitial lung disease, and 1 liver cirrhosis
^bChemotherapy includes 4 patients with T-cell immunosuppressant

ISSN: 1465-993X