Table 4 Change from baseline in trough FEV₁ (mL), according to patient withdrawal, during the 1-year treatment period

Day 29 and still on study at Day 92

88.8 (9.63)

n = 278

121.8 (11.10)

n = 232

113.7 (8.64)

n = 296

Day 92 and still on study at Day 183

84.5 (10.74)

n = 236

100.8 (11.78)

n = 203

104.7 (8.88)

n = 275

Day 183 and still on study at Day 274

73.1 (11.50)

n = 216

98.9 (12.27)

n = 182

94.4 (9.13)

n = 259

Day 274 and still on study at Day 365

68.3 (11.46)

n = 207

65.6 (11.71)

n = 181

86.1 (9.21)

n = 242

Day 29 and withdrew prior to Day 92

73.4 (19.25)

n = 39

130.8 (15.48)

n = 50

130.8 (21.37)

n = 34

Day 92 and withdrew prior to Day 183

93.1 (19.21)

n = 51

97.3 (26.50)

n = 40

42.7 (25.92)

n = 32

Day 183 and withdrew prior to Day 274

99.4 (33.22)

n = 23

137.2 (34.49)

n = 28

143.5 (32.19)

n = 24

Day 274 and withdrew prior to Day 365

83.4 (55.68)

n = 16

60.0 (106.42)

n = 8

57.0 (36.85)

n = 23