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Fig. 5 | Respiratory Research

Fig. 5

From: miR-335-5p inhibits TGF-β1-induced epithelial–mesenchymal transition in non-small cell lung cancer via ROCK1

Fig. 5

Knockdown of ROCK1 inhibits the migratory and invasive ability in A549 and SPC-A1 cells. a-b. qRT-PCR and western blot analysis of ROCK1 expression level in A549 and SPC-A1 cells after transiently transfected with specific siRNA (si-ROCK1) or negative control (si-NC). c-d. The wound healing assay of cells after silencing ROCK1 expression. e-f. The transwell assay showed that knockdown of ROCK1 can inhibit cell migration and invasion in A549 and SPC-A1 cells. g. Western blot analysis of Snail, N-cadherin, Vimentin and MMP2 expression in A549 and SPC-A1 cells after ROCK1 knockdown. *P < 0.05; **P < 0.01; ***P < 0.001

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