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Table 4 Subgroup Analysis: Change in lung function and BMI over time (post-lung resection) by sex (n = 39) and by extent of lung resection (n = 35)

From: Prevalence and course of disease after lung resection in primary ciliary dyskinesia: a cohort & nested case-control study

Outcome Subgroup Intercept (95% CI) p-value Change per year
(95% CI)
p-value*
FVC Z score Males −0.68 0.125 −0.049 0.263
(−1.57, 0.22) (−0.09, − 0.01)
Females −1.65 −0.021
(−3.79, 0.49) (−0.11, 0.07)
FEV1 Z score Males −0.94 0.064 −0.08 0.026
(−1.71, −0.17) (−0.12, − 0.05)
Females −1.96 −0.03
(−3.81, −0.11) (−0.11, 0.04)
BMI Z score Males −0.04 0.180 0.02 0.967
(−0.71, 0.62) (−0.01, 0.05)
Females −0.68 0.02
(−2.27, −0.92) (−0.05, 0.09)
FVC Z score Single Lobe −0.75 0.040 −0.03 0.645
(−1.38, −0.13) (−0.06, − 0.01)
Multiple Lobes −2.49 −0.05
(−4.79, −0.21) (−0.14, 0.04)
FEV1 Z score Single Lobe −1.10 0.012 −0.06 0.955
(−1.61, −0.60) (−0.08, − 0.03)
Multiple Lobes −2.89 −0.06
(−4.78, −0.99) (−0.14, 0.02)
BMI Z score Single Lobe −0.15 0.456 0.02 0.042
(−0.64, 0.35) (0.01, 0.04)
Multiple Lobes −0.62 −0.02
(−2.35, 1.12) (−0.08, 0.04)
  1. *P value for interaction, testing whether the relationship between independent variables (FVC, FEV1, BMI) and time is different within the lobectomised patients between males and females (Subgroup Analysis 1) and between single and multiple lobes resected (Subgroup Analysis 2)