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Table 2 Demographic and Baseline Characteristics by WHO Functional Class and Treatment Group (Primary Analysis Set)

From: Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension

 

Combination Therapy

Pooled Monotherapy

Ambrisentan Monotherapy

Tadalafil Monotherapy

Total (N = 500)

(n = 253)

(n = 247)

(n = 126)

(n = 121)

Baseline Functional Class

FC II

FC III

FC II

FC III

FC II

FC III

FC II

FC III

FC II

FC III

Patients (n)

76

177

79

168

38

88

41

80

155

345

Age, years

 Mean

50

56

53

55

52

55

54

55

52

56

 SD

16

13

15

15

15

14

15

15

15

14

Female

66%

78%

80%

82%

82%

78%

78%

85%

73%

80%

North Americab

53%

43%

53%

42%

53%

35%

54%

49%

53%

42%

Type of PAH

 Idiopathic/ Heritable PAH

53%

53%

58%

59%

58%

60%

59%

58%

55%

56%

 PAH associated with connective tissue diseasea

34%

44%

28%

37%

32%

36%

24%

38%

31%

40%

 PAH associated with congenital heart diseasea

7%

0

4%

1%

3%

0

5%

1%

5%

< 1%

 Hemodynamic variables (mean ± SD)

  Right atrial pressure (mmHg)

N = 76

7 ± 4

N = 176

8 ± 5

N = 79

7 ± 5

N = 167

8 ± 5

N = 38

7 ± 4

N = 87

8 ± 5

N = 41

8 ± 5

N = 80

9 ± 5

N = 155

7 ± 4

N = 343

8 ± 5

  Pulmonary artery pressure (mmHg)

N = 76

47 ± 14

N = 177

49 ± 12

N = 79

46 ± 12

N = 168

51 ± 12

N = 38

47 ± 13

N = 88

52 ± 12

N = 41

45 ± 12

N = 80

50 ± 13

N = 155

46 ± 13

N = 345

50 ± 12

  Pulmonary capillary wedge pressure (mmHg)

N = 72

9 ± 3

N = 172

8 ± 3

N = 77

9 ± 3

N = 159

9 ± 3

N = 38

8 ± 3

N = 83

9 ± 3

N = 39

10 ± 3

N = 76

9 ± 4

N = 149

9 ± 3

N = 331

9 ± 3

  Cardiac index (L/min/m2)

N = 73

2.5 ± 0.7

N = 176

2.4 ± 0.6

N = 79

2.6 ± 0.8

N = 164

2.4 ± 0.6

N = 38

2.7 ± 0.7

N = 87

2.3 ± 0.6

N = 41

2.5 ± 0.9

N = 77

2.4 ± 0.7

N = 152

2.5 ± 0.8

N = 340

2.4 ± 0.6

  Pulmonary vascular resistance, c (dyne/sec/cm5)

N = 76

740 ± 370

N = 177

860 ± 500

N = 79

690 ± 320

N = 168

890 ± 420

N = 38

690 ± 240

N = 88

920 ± 420

N = 41

700 ± 350

N = 80

850 ± 430

N = 155

720 ± 340

N = 345

870 ± 460

  1. FC Functional class, PAH Pulmonary arterial hypertension, SD Standard deviation, WHO World Health Organization
  2. aPost-hoc summary; bNorth America (vs. Rest of World, mostly Western Europe), cValues have been rounded to two significant digits for ease of comparison