Fig. 4

The effects of MINCR silencing on c-Myc and its downstream effectors. a-b, The protein expression levels (a) and statistic graphs (b) of c-Myc and its downstream effectors Cyclin A, Cyclin D, CDK4, and CDK2 in PC9 cells with or without MINCR silencing. c-d, The protein expression levels (c) and statistic graphs (d) of Bcl-2, Bax and PARP-1 (full length and cleaved forms) in PC9 cells with or without MINCR silencing. e-f, The protein expression levels (e) and statistic graphs (f) of c-Myc and its downstream effectors Cyclin A, Cyclin D, CDK4, and CDK2 in A549 cells with or without MINCR silencing. g-h, The protein expression levels (g) and statistic graphs (h) of Bcl-2, Bax and PARP-1 (full length and cleaved forms) in A549 cells with or without MINCR silencing. Each experiment was repeated independently at least three times. Data were presented as mean ± SD; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001