Plasma metabolomics and clinical predictors of survival differences in COPD patients

Respiratory Research

Table 1 Clinical characteristics of COPD patients and control population

Variables	COPD (NS d)	COPD (NS v)	COPD (S)	Controls	p value
N	30	30	30	30
Age (y)	67 ± 10	71 ± 8	68 ± 7	68 ± 7	0.72
Male, %	68	70	59	67	0.73
BMI (kg/m²)	25.8 ± 5	26.7 ± 5	27.3 ± 4	28.8 ± 5	0.05
Smoking (p/y)	68 ± 36	65 ± 6	60 ± 38	58 ± 30	0.5
FVC, %	71 ± 26	70 ± 18	79 ± 14	104 ± 16	< 0.001
FEV1, %	35 ± 12	46 ± 20	45 ± 15	99 ± 17	< 0.001
FRC, %	181 ± 48	153 ± 46	155 ± 47	97 ± 24	< 0.001
DLCO, %	44 ± 14	56 ± 23	64 ± 22	91 ± 24	< 0.001
IC/TLC	0.22 ± 0.06	0.27 ± 0.08	0.33 ± 0.12	0.47 ± 0.09	< 0.001
mMRC	2.7 ± 0.6	1.7 ± 1.4	1.5 ± 1.1	0.13 ± 0.3	< 0.001
6MWT(m)	301 ± 92	408 ± 77	442 ± 125	543 ± 113	< 0.001
BODE	5.3 ± 1.6	3.1 ± 2.2	3 ± 1.9	N/A	< 0.001
GOLD 2,3,4, %	6,52,42	40,37,23	34,52,14	N/A	< 0.001
SGRQ	56 ± 15	50 ± 12	42 ± 25	11 ± 13	< 0.001
Charlson CI	0.8 ± 1.2	0.6 ± 1.2	0.5 ± 1.1	0.3 ± 0.7	0.30
PaO₂ (mmHg)	65 ± 14	58 ± 10	76 ± 11	N/A	< 0.002
PaCO₂ (mmHg)	46 ± 9	45 ± 6	40 ± 3	N/A	< 0.002

NS d Non-survivor discovery. NS v Non-survivor validation S Survivors. Charlson CI Charlson Comorbidity Index. N/A Non-applicable

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