Fig. 7From: Lyn regulates epithelial–mesenchymal transition in CS-exposed model through Smad2/3 signalingSchematic of Lyn regulates EMT through Smad2/3 signaling in CS-exposed model. In CS-exposed model, not only the expression of Lyn, but also the phosphorylation of Lyn was increased. Then phosphorylation of Smad2/3 was up-regulated by activated Lyn through a direct or indirect way, and more phosphorylated Smad2/3 moved into nucleus. In nucleus, phosphorylated Smad2/3 functioned as major transcription factors to regulate the expression of EMT makers, promoted EMT in CS-exposed modelBack to article page