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Table 2 Baseline measures of genetic expression (fold-change) by cigarette smoking status

From: Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD

 

Former Smoker

N = 34

Current Smoker N = 53

P-value*

 

Median (IQR)

Bronchial epithelial cells

 NRF2

0.83 (0.65–1.17)

1.03 (0.91–1.26)

0.010

 NQO1

0.56 (0.36–0.75)

1.61 (1.01–2.22)

<.001

 HO1

0.64 (0.31–0.92)

1.29 (0.61–1.87)

<.001

 AKR1C1

0.58 (0.31–0.94)

1.72 (0.76–2.64)

<.001

 AKR1C3

0.64 (0.36–1.05)

1.54 (0.98–2.34)

<.001

 Keap1

0.97 (0.64–1.25)

1.16 (0.89–1.53)

0.03

Alveolar macrophages

 NRF2

1.32 (0.94–1.72)

1.05 (0.77–1.42)

0.05

 NQO1

0.65 (0.47–1.70)

1.11 (0.62–2.05)

0.18

 HO1

1.12 (0.76–1.44)

0.99 (0.74–1.25)

0.33

 AKR1C1

1.34 (0.64–4.49)

0.88 (0.57–2.88)

0.20

 AKR1C3

0.97 (0.53–1.48)

1.11 (0.85–1.68)

0.29

 Keap1

0.91 (0.70–1.44)

0.99 (0.79–1.32)

0.83

Nasal epithelial cells

 NRF2

1.00 (0.80–1.13)

1.10 (0.78–1.41)

0.13

 NQO1

1.05 (0.59–1.80)

1.00 (0.56–2.05)

0.92

 AKR1C3

1.21 (0.67–1.97)

1.13 (0.69–2.46)

0.79

 AKR1B10

0.67 (0.39–1.59)

2.19 (0.99–4.43)

0.001

PBMC

 NRF2

0.85 (0.69–1.04)

1.05 (0.82–1.43)

0.009

 NQO1

0.85 (0.53–1.04)

0.92 (0.64–1.25)

0.30

 HO1

1.43 (1.12–1.68)

1.07 (0.84–1.37)

0.003

 AKR1C1

1.82 (0.40–6.73)

0.73 (0.37–8.88)

0.82

 AKR1C3

0.72 (0.51–1.16)

0.89 (0.51–1.13)

0.61