Fig. 3
From: IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1
IL-22Ra1 induction by Type I and Type II interferons but not Type III. A549s were treated with 50 units/ml of IFNβ, IFNγ, and IFNλ respectively. Cells were collected in trizol after 6 h and RNA isolated for RT-qPCR analysis. IFNβ treatment lead to significant induction of IL-22Ra1 when compared to all other groups (one-way ANOVA, p < 0.0001). IFNγ treatment led to lower albeit significant induction of IL-22Ra1 than IFNβ (one-way ANOVA, p = 0.0002). IFNλ treatment had no effect on expression of IL-22Ra1. Representative of two experiments