Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial

Respiratory Research

Table 4 Changes of gene expression level and their relationship to 1-year mortality in study 2

Gene	Gene name	Change in gene expression level with prednisone	1-year mortality
Gene	Gene name	Change in gene expression level with prednisone	HR [95% CI]	P-value
CX3CR1	chemokine (C-X3-C motif) receptor 1	down	1.69 [1.01, 2.84]	0.0452
C1orf21	chromosome 1 open reading frame 21	down	1.69 [1.06, 2.68]	0.0276
KLRD1	killer cell lectin-like receptor subfamily D, member 1	down	1.67 [1.08, 2.60]	0.0215
S1PR5	sphingosine-1-phosphate receptor 5	down	1.65 [1.03, 2.62]	0.0364
ADGRG5	adhesion G protein-coupled receptor G5	down	1.63 [1.10, 2.43]	0.0160
PRF1	perforin 1 (pore forming protein)	down	1.63 [1.04, 2.57]	0.0346
TGFBR3	transforming growth factor beta receptor III	down	1.61 [1.05, 2.47]	0.0274
CYSLTR2	cysteinyl leukotriene receptor 2	down	1.57 [1.11, 2.22]	0.0108
NKG7	natural killer cell granule protein 7	down	1.43 [1.02, 2.02]	0.0393
DHRS9	dehydrogenase/reductase (SDR family) member 9	down	0.73 [0.54, 0.98]	0.0366

HR = decreased level of gene expression hazard rate / increased level of gene expression hazard rate from baseline to convalescence
HR hazard ratio, 95% CI 95% confidence interval

ISSN: 1465-993X