Table 3 Enrichment analysis: Biological process and pathway regulated by prednisone in study 1
Biological process and pathway | P-value | FDR | Genes |
|---|---|---|---|
Immune response | 2.57E-07 | 8.40E-05 | KLRD1, TGFBR3, IKBKE, GZMA, CX3CR1, SPON2, MILR1, NCR1, SLAMF7, CYSLTR2, NFKB2, CD36, PRF1, NR1D1, PAG1 |
Cytolysis | 1.19E-06 | 2.00E-04 | GZMA, PRF1, GZMB, GZMH |
Graft-versus-host disease | 1.43E-05 | 3.60E-05 | KLRD1, PRF1, GZMB |
Natural killer cell mediated cytotoxicity | 1.80E-05 | 3.60E-05 | KLRD1, PRF1, GZMB, NCR1 |
Cellular defense response | 2.87E-05 | 0.0028 | PRF1, CX3CR1, GNLY, NCR1 |
Immune system process | 3.44E-05 | 0.0028 | KLRD1, GZMA, CX3CR1, NCR1, SLAMF7, ID2, CYSLTR2, CD36, PAG1, TGFBR3, IKBKE, MILR1, SPON2, NFKB2, NR1D1, PRF1 |
Circadian rhythm | 0.0001 | 0.0065 | ID2, PRF1, NR1D1, PER2 |
cell activation | 0.0003 | 1.40E-02 | CX3CR1, MILR1, NCR1, SLAMF7, ID2, NFKB2, CD36, STXBP1, PAG1 |
Natural killer cell activation | 0.0003 | 1.40E-02 | ID2, SLAMF7, NCR1 |
Regulation of immune system process | 0.0009 | 3.68E-02 | KLRD1, IKBKE, MILR1, NCR1, ID2, NFKB2, NR1D1, CD36, PAG1 |
Cell killing | 0.0011 | 3.92E-02 | SLAMF7, GNLY, NCR1 |
Regulation of immune response | 0.0012 | 3.92E-02 | KLRD1, IKBKE, NFKB2, CD36, NR1D1, PAG1, NCR1 |
Defense response | 0.0014 | 4.16E-02 | IKBKE, CX3CR1, SPON2, NCR1, SLAMF7, NFKB2, CD36, NR1D1, PRF1, GNLY |
Neuroactive ligand-receptor interaction | 0.0037 | 4.90E-03 | CYSLTR2, GZMA, S1PR5 |
Metabolic pathways | 0.0392 | 3.92E-02 | PIGB, AMPD3, DHRS9, ENO1 |