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Table 2 Gene function annotation enrichment analysis of the top up-regulated and down-regulated genes during differentiation on ALI culturea

From: Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

Term Gene numberb Percentage of genes in the list (%) p valuec p value after Benjamini-Hochberg correction
Top up-regulated
 Cilium 68 4.7 2.3 × 10−28 1.1 × 10−25
 Cell projection 127 8.9 1.9 × 10−23 4.6 × 10−21
 Immunity 101 7.0 3.4 × 10−23 5.3 × 10− 21
Top down-regulated
 Ribosomal protein 92 6.3 5.1 × 10−57 2.5 × 10−54
 Ribonucleoprotein 102 6.9 4.0 × 10−45 9.6 × 10−43
 Acetylation 380 25.9 2.6 × 10−26 4.1 × 10−24
  1. aFunction term annotation enrichment analysis was carried out using DAVID analysis (https://david.ncifcrf.gov/tools.jsp). The fold-changes of RNAseq data between hSABCi NS1.1 cells on ALI-day 28 was compared to basal cells before ALI culture. The top 1500 up-regulated genes and top 1500 down-regulated genes were used for analysis. The top 3 enriched functional terms in the results were shown. See Methods for detail
  2. bNumbers of genes with the function described in “Term”
  3. cp value is from a modified Fisher exact test, indicating whether the gene list is enriched with an annotated function or not