Skip to main content
Fig. 7 | Respiratory Research

Fig. 7

From: Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

Fig. 7

Expression of small airway development-relevant transcription factors in immortalized hSABCi-NS1.1 cells. Gene expression in hSABCi-NS1.1 cells (from small airway) was compared with gene expression in BCi-NS1.1 cells (from large airway). Both cell lines (passage 52–55) were cultured on ALI using identical culture conditions for comparison. Large and small airway lineage markers and transcription factors relevant to the development of large airway (SOX2) and small airway (NKX2–1, GATA6, SOX9, HOPX, ID2 and ETV5) were assessed by TaqMan PCR. Data shown is the mean fold-changes ± standard error of n = 3 independent side-by-side comparison experiments. *, p < 0.05; **, p < 0.01; #, consistent changes in all 3 independent experiments, but not significant because of high variability. a Airway cell lineage marker genes. b Transcription factors relevant to the development of large airway and small airway epithelium

Back to article page