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Fig. 2 | Respiratory Research

Fig. 2

From: Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD)

Fig. 2

Defective glycolytic and mitochondrial metabolism in PBMCs of COPD subjects. % Change in OCR (a) in PBMCs from 16 healthy non-smokers (HNS), 10 healthy smokers (HS) and 13 tobacco smoking COPD (TS-COPD) subjects while metabolizing glucose (10 mM), pyruvate (2 mM) and palmitate-BSA (200 μM) measured using the XF Extracellular Flux analyzer as described in the material and methods section. % Change in ECAR (b) in PBMCs while metabolizing glucose (10 mM) was measured as described in the material and methods section. c GAPDH enzyme activity measured by monitoring consumption of NAD at 340 nm in 15 HNS, 13 HS and 10 TS-COPD subjects. Median values are indicated with a line for each group and * p < 0.05, ** p < 0.01 vs HNS; # p < 0.05 Vs HS was considered as statistically significant using the Mann-Whitney U test. Correlation analysis of fatty acid metabolism with lung function parameters showed a strong positive correlation between palmitate OCR and FEV1 (D) and FVC (E) for 10 healthy smokers as shown

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