TY - JOUR AU - Edris, Ahmed AU - De Feyter, Silke AU - Maes, Tania AU - Joos, Guy AU - Lahousse, Lies PY - 2019 DA - 2019/08/08 TI - Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis JO - Respiratory Research SP - 179 VL - 20 IS - 1 AB - Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate. PubMed and Web of Science were searched for phase II and phase III randomized clinical trials with monoclonal antibodies targeting key mediators of type 2-associated asthma. Thirty trials were selected involving biologics that target the IL-5 pathway, IL-13, the common IL-4 and IL-13 receptor, IL-9, IL-2 and TSLP. As no head-to-head trials were retrieved from literature, we performed an arm-based network meta-analysis to compare effects on exacerbation rate between the different treatments. SN - 1465-993X UR - https://doi.org/10.1186/s12931-019-1138-3 DO - 10.1186/s12931-019-1138-3 ID - Edris2019 ER -