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Fig. 2 | Respiratory Research

Fig. 2

From: Use of precision cut lung slices as a translational model for the study of lung biology

Fig. 2

Translational studies of asthma using mouse model and PCLS. Asthmatic patient experiences airway obstruction and hyperresponsiveness, bronchoconstriction as well as airway inflammation (eosinophilic and/or neutrophilic). Mouse model of allergic asthma induced by ovalbumin or house dust mite mimics relevant features of human allergic asthma upon allergic sensitization and challenge, resulting in allergen-specific response of airways. Asthmatic PCLS obtained from mouse and patients show significantly enhanced airway inflammation and hyperresponsiveness following stimulation of allergens and infections

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