Fig. 2From: Use of precision cut lung slices as a translational model for the study of lung biologyTranslational studies of asthma using mouse model and PCLS. Asthmatic patient experiences airway obstruction and hyperresponsiveness, bronchoconstriction as well as airway inflammation (eosinophilic and/or neutrophilic). Mouse model of allergic asthma induced by ovalbumin or house dust mite mimics relevant features of human allergic asthma upon allergic sensitization and challenge, resulting in allergen-specific response of airways. Asthmatic PCLS obtained from mouse and patients show significantly enhanced airway inflammation and hyperresponsiveness following stimulation of allergens and infectionsBack to article page