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Table 3 Risk factors for acute exacerbation in pulmonary and non-pulmonary surgeries

From: Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study

Charactaristics

Pulmonary surgeries

Non-pulmonary surgeries

OR

(95% CI)

P value

OR

(95% CI)

P value

Age, median

0.997

(0.941–1.094)

p = 0.940

0.951

(0.868–1.057)

p = 0.332

Sex Male −/a

1.261

(0.179–25.09)

p = 0.835

NC

NC

NC

BMI (kg/m2)

0.817

(0.601–1.055)

p = 0.129

1.114

(0.855–1.438)

p = 0.414

History of smoking a/−

1.779

(0.586–20.47)

p = 0.224

1.099

(0.103–26.63

p = 0.944

IPF or other IP, IPF

6.618

(0.949–131.1)

p = 0.569

2.299

(0.272–19.40)

p = 0.415

Corticosteroid therapy −/a

35.750

(1.267–1026)

p = 0.039†

0.517

(0.044–1.570)

p = 0.176

Past acute exacerbation −/a

36.250

(1.285–1040)

p = 0.038†

2.039

(0.174–6.686)

p = 1.000

HRCT findings

 UIP pattern

4.343

(0.624–86.00)

p = 0.146

1.242

(0.147–10.46)

p = 0.830

 Emphysema

4.000

(0.575–79.20)

p = 0.172

1.740

(0.206–14.67)

p = 0.585

Pulmonary function test

 %VC

0.985

(0.931–1.039)

p = 0.582

0.978

(0.924–1.035)

p = 0.445

 %VC < 80%

2.115

(0.096–22.89)

p = 0.566

1.508

(0.069–16.02)

p = 0.745

 FEV1/FVC

0.986

(0.894–1.101)

p = 0.791

1.014

(0.915–1.157)

p = 0.820

 %DLCO

1.039

(0.995–1.087)

p = 0.081

1.000

(0.997–1.003)

p = 0.946

KL-6

1.000

(0.999–1.001)

p = 0.469

1.000

(0.997–1.003)

p = 0.601

KL-6 > 1000 U/mL −/a

1.150

(0.058–8.193)

p = 0.904

3.765

(0.857–45.74)

p = 0.113

LDH

1.012

(0.995–1.027)

p = 0.153

1.004

(0.999–1.007)

p = 0.125

CRP

1.126

(0.844–1.345)

p = 0.324

1.187

(1.073–1.344)

p = 0.002†

JACS risk score

1.554

(0.983–2.780)

p = 0.061

1.363

(0.779–2.301)

p = 0.261

Emergency surgery

NC

NC

NC

8.363

(0.396–71.64)

p = 0.139

Tumor surgery

0.855

(0.138–6.643)

p = 0.867

1.391

(0.165–11.72)

p = 0.743

Neoadjuvant chemotherapy a/−

2.936

(0.235–14.01)

p = 1.000

9.909

(0.375–262.9)

p = 0.144

Anesthesia time

1.002

(0.993–1.009)

p = 0.733

1.002

(0.996–1.006)

p = 0.406

Amount of bleeding

0.999

(0.992–1.003)

p = 0.778

1.000

(0.998–1.000)

p = 0.866

Lung infection a/a

1.088

(0.093–3.421)

p = 1.000

1.912

(0.164–6.234)

p = 1.000

 (surgical complication)

      
  1. OR odds ratio, CI confidence interval, NC not calculable, BMI body mass index, IPF idiopathic pulmonary fibrosis, HRCT high solution computed tomography, UIP usual interstitial pneumonia, VC vital capacity, FEV1/FVC forced expiratory volume in 1 second/forced vital capacity, DLCO diffusing capacity for carbon monoxide, KL-6 Klebs von den Lungen-6, LDH lactate dehydrogenase, CRP C-reactive protein, JACS Japanese association for chest surgery
  2. †; P value < 0.05, Logistic regression analysis, aPenalized Firth correction applied due to quasi-complete data separation