Fig. 4

Effect of 3 month change in neoepitope concentrations on overall survival. Subjects with IPF were dichotomised into HIGH or LOW groups, to determine the effect of 3-month change in neoepitope concentration on overall survival, where: HIGH = rising (0 > ng/mL per month) neoepitope concentrations from baseline to month 3, >or LOW = stable or falling (≤0 ng/mL per month) neoepitope concentration from baseline to month 3. For ratio values, the slope values were derived following the creation of the ratio variables and subjects were dichotomised into HIGH or LOW slope groups. Hazard ratio represents the mortality risk in participants with rising neoepitope concentrations relative to those with stable or falling concentrations. Data shown in: top panel - collagen synthesis markers P1NP, PRO-C3, PRO-C6; mid panel - ratio of collagen synthesis/degradation markers: P1NP:C1M, PRO-C3:C3M and PRO-C6:C6M; bottom panel -BGM, C1M, C3M, C6M, CRPM). The number of deaths in each group is shown for each biomarker. P values presented relate to the comparison of the Kaplan-Meir survival curves for each dichotomised measure