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Fig. 2 | Respiratory Research

Fig. 2

From: Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort

Fig. 2

Comparisons of neoepitope concentrations for collagen synthesis markers in healthy control and participants with stable and progressive IPF, measured at baseline, 1, 3 and 6 months after baseline for collagen-type 1 (P1NP), −type 3 (PRO-C3) and -type 6 (PRO-C6). Plots represent mean and 95% CI (error bars) adjusted for age, sex, site and smoking status. Disease progression was defined as all-cause mortality or 10% decline in forced vital capacity at 12 months. The number of evaluable samples available for analysis at each time point are provided in the graph. P values are provided where significant (p < 0.05) differences were observed between stable and progressive disease at a particular time point. Triangles represent which groups were compared at each time point on the graph, based on colour

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