Table 5 Significant variants in COL6A3 associated with lung risk in patients with lung adenocarcinoma and lung squamous carcinoma
From: COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population
SNP | Model | Genotype | Control (%) | Case (%) | Without Adjustment | Adjustment by gender and age | |||
|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | p-value | OR (95%CI) | p-value | ||||||
Lung adenocarcinoma | |||||||||
COL6A3 | rs13032404 | Codominant | A/A | 95 (27.5) | 71 (20.0) | 1.00 | 1.00 | ||
A/T | 163 (47.3) | 165 (46.5) | 0.93 (0.64–1.35) | 0.703 | 0.92 (0.63–1.34) | 0.672 | |||
T/T | 87 (25.2) | 119 (33.5) | 1.56 (0.95–2.59) | 0.768 | 1.46 (0.88–2.44) | 0.146 | |||
Dominant | A/A | 95 (27.5) | 71 (20.0) | 1.00 | 0.018 | 1.00 | 0.869 | ||
A/T-T/T | 250 (35.1) | 284 (80.0) | 1.05 (0.74–1.49) | 1.03 (0.72–1.46) | |||||
Recessive | A/A-A/T | 258 (95.3) | 236 (66.5) | 1.00 | 0.038 | 1.00 | 0.076 | ||
T/T | 87 (25.2) | 119 (33.5) | 1.63 (0.92–2.58) | 1.53 (0.96–2.44) | |||||
Log-additive | – | – | – | 1.17 (0.92–1.50) | 0.204 | 1.14 (0.89–1.46) | 0.305 | ||
Lung Squamous Carcinoma | |||||||||
COL6A3 | rs13032404 | Codominant | A/A | 95 (27.5) | 71 (20.0) | 1.00 | 1.00 | ||
A/T | 163 (47.3) | 165 (46.5) | 1.51 (0.96–2.36) | 0.074 | 1.57 (0.99–2.49) | 0.054 | |||
T/T | 87 (25.2) | 119 (33.5) | 1.56 (0.82–2.99) | 0.177 | 1.64 (0.84–3.18) | 0.147 | |||
Dominant | A/A | 95 (27.5) | 71 (20.0) | 1.00 | 0.059 | 1.00 | 0.042 | ||
A/T-T/T | 250 (35.1) | 284 (80.0) | 1.52 (0.98–2.34) | 1.58 (1.02–2.47) | |||||
Recessive | A/A-A/T | 258 (95.3) | 236 (66.5) | 1.00 | 0.508 | 1.00 | 0.475 | ||
T/T | 87 (25.2) | 119 (33.5) | 1.22 (0.68–2.18) | 1.24 (0.68–2.26) | |||||
Log-additive | – | – | – | 1.30 (0.96–1.76) | 0.086 | 1.34 (0.98–1.82) | 0.064 | ||
rs115510139 | Codominant | A/A | 131 (26.7%) | 108 (21.2%) | 1.00 | 1.00 | |||
A/T | 232 (47.3%) | 235 (46.1%) | 1.64 (0.94–2.84) | 0.080 | 1.68 (0.96–2.95) | 0.007 | |||
T/T | 127 (26.0%) | 167 (32.7%) | 2.17 (1.21–3.89) | 0.010 | 2.27 (1.25–4.13) | 0.007 | |||
Dominant | A/A | 131 (26.7%) | 108 (21.2%) | 1.00 | 1.00 | ||||
T/A-T/T | 359 (73.3%) | 402 (78.8%) | 1.83 (1.09–3.07) | 0.024 | 1.89 (1.11–3.20) | 0.019 | |||
Recessive | A/A-A/T | 363 (74.0%) | 343 (67.3%) | 1.00 | 0.047 | 1.00 | 0.040 | ||
T/T | 127 (26.0%) | 167 (32.7%) | 1.54 (1.01–2.36) | 1.59 (1.02–2.46) | |||||
Log-additive | – | – | – | 1.45 (1.10–1.92) | 0.010 | 1.48 (1.11–1.98) | 0.007 | ||
rs3736341 | Codominant | T/T | 177 (53.5) | 214 (61.7) | 1.00 | 1.00 | |||
T/C | 126 (38.1) | 109 (31.4) | 0.69 (0.44–1.07) | 0.096 | 0.68 (0.43–1.07) | 0.098 | |||
C/C | 28 (8.4) | 24 (6.9) | 0.32 (0.11–0.91) | 0.033 | 0.33 (0.11–0.95) | 0.040 | |||
Dominant | T/T | 177 (53.5) | 214 (61.7) | 1.00 | 0.025 | 1.00 | 0.027 | ||
T/C-C/C | 154 (46.5) | 133 (38.3) | 0.62 (0.40–0.94) | 0.61 (0.40–0.95) | |||||
Recessive | T/T-T/C | 303 (91.6) | 323 (93.1) | 1.00 | 0.057 | 1.00 | 0.068 | ||
C/C | 28 (8.4) | 24 (6.9) | 0.36 (0.13–1.03) | 0.37 (0.13–1.07) | |||||
Log-additive | – | – | – | 0.63 (0.44–0.90) | 0.010 | 0.63 (0.44–0.91) | 0.012 | ||