Table 4 Significant variants in COL6A3 associated with lung susceptibility after stratified by age of 61 years
From: COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population
Gene | SNP | Model | Genotype | Control | Case | Age>61 years | Age ≤ 61 years | ||
|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | p-value | OR (95%CI) | p-value | ||||||
COL6A3 | rs115510139 | Codominant | A/A | 131 (26.7%) | 108 (21.2%) | 1.00 | 1.00 | ||
A/T | 232 (47.3%) | 235 (46.1%) | 0.77 (0.51–1.16) | 0.212 | 1.40 (0.89–2.21) | 0.143 | |||
T/T | 127 (26.0%) | 167 (32.7%) | 0.71 (0.43–1.16) | 0.167 | 1.84 (1.12–3.03) | 0.016 | |||
Dominant | A/A | 131 (26.7%) | 108 (21.2%) | 1.00 | 0.142 | 1.00 | 0.037 | ||
T/A-T/T | 359 (73.3%) | 402 (78.8%) | 0.75 (0.51–1.10) | 1.56 (1.03–2.38) | |||||
Recessive | A/A-A/T | 363 (74.0%) | 343 (67.3%) | 1.00 | 0.393 | 1.00 | 0.055 | ||
T/T | 127 (26.0%) | 167 (32.7%) | 0.83 (0.55–1.27) | 1.48 (0.99–2.22) | |||||
Log-additive | – | – | – | 0.84 (0.66–1.07) | 0.154 | 1.36 (1.06–1.74) | 0.016 | ||