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Table 2 An epidermal barrier fingerprint is seen after 22 days of Azm treatment

From: Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia

Transcript ID

q-value

Fold enrichment

Gene ID

Gene name

GO categories

ENST00000252244.3

3,69E-115

3,90

KRT1

Keratin, type II cytoskeletal 1

peptide cross-linking, keratinization, neutrophil degranulation, establishment of skin barrier, cornification

ENST00000259726.6

5,84E-70

3,21

CDSN

Corneodesmosin

cell adhesion, epidermis development, keratinocyte differentiation, cornification

ENST00000368787.3

5,29E-69

3,07

LCE3D

Late cornified envelope protein 3D

peptide cross-linking, keratinocyte differentiation, cornification

ENST00000514033.1

2,47E-65

2,83

KLF3

Krueppel-like factor 3

negative regulation of transcription from RNA polymerase II promoter, multicellular organism development

ENST00000301659.8

7,11E-62

2,78

GSDMA

Gasdermin-A

apoptotic process

ENST00000425231.2

3,37E-61

3,34

CDCP1

CUB domain-containing protein 1

protein binding, extracellular region

ENST00000246635.7

1,08E-60

-2,77

KRT13

Keratin, type I cytoskeletal 13

cytoskeleton organization, keratinization, cornification

ENST00000395254.7

1,08E-60

6,04

ZNF365

Protein ZNF365

telomere maintenance,protein binding,cytoplasm

ENST00000369091.6

1,10E-57

7,37

PRDM1

PR domain zinc finger protein 1

negative regulation of transcription from RNA polymerase II promoter, positive regulation of gene expression

ENST00000557785.5

1,95E-53

6,85

MEF2A

Myocyte-specific enhancer factor 2A

negative regulation of transcription from RNA polymerase II promoter, apoptotic process, dendrite morphogenesis

ENST00000409458.3

6,14E-52

3,61

GPNMB

Transmembrane glycoprotein NMB

cell adhesion, signal transduction, negative regulation of cell proliferation

ENST00000311946.7

6,12E-51

2,40

NIPAL4

Magnesium transporter NIPA4

magnesium ion transmembrane transporter activity

ENST00000313234.9

5,04E-49

2,81

KRT80

Keratin, type II cytoskeletal 80

keratinization, cornification

ENST00000252252.3

1,03E-48

2,49

KRT6B

Keratin, type II cytoskeletal 6B

cytoskeleton organization, keratinization, cornification

ENST00000335585.9

1,87E-48

2,57

PPP2R2C

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

protein phosphatase type 2A complex

ENST00000605952.5

1,51E-47

2,32

ATG9B

Autophagy-related protein 9B

autophagosome assembly, protein localization to phagophore assembly site

ENST00000293502.1

8,18E-47

3,11

SDR9C7

Short-chain dehydrogenase/reductase family 9C member 7

retinol dehydrogenase activity, nucleolus

ENST00000244360.6

9,75E-45

2,26

RNF39

RING finger protein 39

cellular_component, cytoplasm

ENST00000395641.2

5,65E-44

2,24

NUPR1

Nuclear protein 1

positive regulation of protein modification process, negative regulation of cell cycle

ENST00000269703.7

1,58E-43

2,20

CYP4F22

Cytochrome P450 4F22

monooxygenase activity,iron ion binding,endoplasmic reticulum membrane

ENST00000377950.7

7,18E-43

2,27

LYPD5

Ly6/PLAUR domain-containing protein 5

extracellular region,plasma membrane

ENST00000224784.10

4,78E-42

-2,29

ACTA2

Actin, aortic smooth muscle

positive regulation of gene expression

ENST00000522476.5

8,87E-42

2,45

NDRG1

Protein NDRG1

negative regulation of cell proliferation, DNA damage response, signal transduction by p53 class mediator, regulation of apoptotic process, cellular response to hypoxia

ENST00000329078.7

1,01E-41

2,17

SPNS2

Protein spinster homolog 2

sphingolipid metabolic process, locomotion

ENST00000393200.6

2,04E-40

2,70

IL36RN

Interleukin-36 receptor antagonist protein

negative regulation of cytokine-mediated signaling pathway,cytokine activity,interleukin-1 receptor binding

ENST00000317216.2

1,66E-39

2,08

EGR3

Early growth response protein 3

positive regulation of endothelial cell proliferation,cell migration involved in sprouting angiogenesis

ENST00000368087.7

5,45E-38

2,83

ARG1

Arginase-1

neutrophil degranulation

ENST00000372789.5

4,313E-37

2,02

WFDC5

WAP four-disulfide core domain protein 5

serine protease inhibitor

ENST00000234396.8

6,879E-35

-2,15

ATP6V1B1

V-type proton ATPase subunit B, kidney isoform

ossification,ATP binding,cytoplasm,cytosol,microvillus

ENST00000447113.6

1,713E-33

2,06

DMKN

Dermokine

keratinocytes, differentiation of epidermis