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Table 2 An epidermal barrier fingerprint is seen after 22 days of Azm treatment

From: Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia

Transcript ID q-value Fold enrichment Gene ID Gene name GO categories
ENST00000252244.3 3,69E-115 3,90 KRT1 Keratin, type II cytoskeletal 1 peptide cross-linking, keratinization, neutrophil degranulation, establishment of skin barrier, cornification
ENST00000259726.6 5,84E-70 3,21 CDSN Corneodesmosin cell adhesion, epidermis development, keratinocyte differentiation, cornification
ENST00000368787.3 5,29E-69 3,07 LCE3D Late cornified envelope protein 3D peptide cross-linking, keratinocyte differentiation, cornification
ENST00000514033.1 2,47E-65 2,83 KLF3 Krueppel-like factor 3 negative regulation of transcription from RNA polymerase II promoter, multicellular organism development
ENST00000301659.8 7,11E-62 2,78 GSDMA Gasdermin-A apoptotic process
ENST00000425231.2 3,37E-61 3,34 CDCP1 CUB domain-containing protein 1 protein binding, extracellular region
ENST00000246635.7 1,08E-60 -2,77 KRT13 Keratin, type I cytoskeletal 13 cytoskeleton organization, keratinization, cornification
ENST00000395254.7 1,08E-60 6,04 ZNF365 Protein ZNF365 telomere maintenance,protein binding,cytoplasm
ENST00000369091.6 1,10E-57 7,37 PRDM1 PR domain zinc finger protein 1 negative regulation of transcription from RNA polymerase II promoter, positive regulation of gene expression
ENST00000557785.5 1,95E-53 6,85 MEF2A Myocyte-specific enhancer factor 2A negative regulation of transcription from RNA polymerase II promoter, apoptotic process, dendrite morphogenesis
ENST00000409458.3 6,14E-52 3,61 GPNMB Transmembrane glycoprotein NMB cell adhesion, signal transduction, negative regulation of cell proliferation
ENST00000311946.7 6,12E-51 2,40 NIPAL4 Magnesium transporter NIPA4 magnesium ion transmembrane transporter activity
ENST00000313234.9 5,04E-49 2,81 KRT80 Keratin, type II cytoskeletal 80 keratinization, cornification
ENST00000252252.3 1,03E-48 2,49 KRT6B Keratin, type II cytoskeletal 6B cytoskeleton organization, keratinization, cornification
ENST00000335585.9 1,87E-48 2,57 PPP2R2C Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform protein phosphatase type 2A complex
ENST00000605952.5 1,51E-47 2,32 ATG9B Autophagy-related protein 9B autophagosome assembly, protein localization to phagophore assembly site
ENST00000293502.1 8,18E-47 3,11 SDR9C7 Short-chain dehydrogenase/reductase family 9C member 7 retinol dehydrogenase activity, nucleolus
ENST00000244360.6 9,75E-45 2,26 RNF39 RING finger protein 39 cellular_component, cytoplasm
ENST00000395641.2 5,65E-44 2,24 NUPR1 Nuclear protein 1 positive regulation of protein modification process, negative regulation of cell cycle
ENST00000269703.7 1,58E-43 2,20 CYP4F22 Cytochrome P450 4F22 monooxygenase activity,iron ion binding,endoplasmic reticulum membrane
ENST00000377950.7 7,18E-43 2,27 LYPD5 Ly6/PLAUR domain-containing protein 5 extracellular region,plasma membrane
ENST00000224784.10 4,78E-42 -2,29 ACTA2 Actin, aortic smooth muscle positive regulation of gene expression
ENST00000522476.5 8,87E-42 2,45 NDRG1 Protein NDRG1 negative regulation of cell proliferation, DNA damage response, signal transduction by p53 class mediator, regulation of apoptotic process, cellular response to hypoxia
ENST00000329078.7 1,01E-41 2,17 SPNS2 Protein spinster homolog 2 sphingolipid metabolic process, locomotion
ENST00000393200.6 2,04E-40 2,70 IL36RN Interleukin-36 receptor antagonist protein negative regulation of cytokine-mediated signaling pathway,cytokine activity,interleukin-1 receptor binding
ENST00000317216.2 1,66E-39 2,08 EGR3 Early growth response protein 3 positive regulation of endothelial cell proliferation,cell migration involved in sprouting angiogenesis
ENST00000368087.7 5,45E-38 2,83 ARG1 Arginase-1 neutrophil degranulation
ENST00000372789.5 4,313E-37 2,02 WFDC5 WAP four-disulfide core domain protein 5 serine protease inhibitor
ENST00000234396.8 6,879E-35 -2,15 ATP6V1B1 V-type proton ATPase subunit B, kidney isoform ossification,ATP binding,cytoplasm,cytosol,microvillus
ENST00000447113.6 1,713E-33 2,06 DMKN Dermokine keratinocytes, differentiation of epidermis