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Table 1 Azm induces global gene expression changes in airway epithelia

From: Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia

Day 4

Day 10

Day 22

GO biological process complete

fold enrichment

raw P-value

GO biological process complete

fold enrichment

raw P-value

GO biological process complete

fold enrichment

raw P-value

negative regulation of platelet activation (GO:0010544)

47,39

5,25E-05

positive regulation of receptor catabolic process (GO:2000646)

56,36

6,21E-05

desmosome organization (GO:0002934)

17,34

8,23E-06

ovulation (GO:0030728)

44,9

6,06E-05

intracellular cholesterol transport (GO:0032367)

25,05

4,10E-05

establishment of skin barrier (GO:0061436)

15,9

2,49E-09

negative regulation of hemostasis (GO:1900047)

23,21

3,57E-05

intracellular sterol transport (GO:0032366)

23,48

5,09E-05

regulation of water loss via skin (GO:0033561)

14,45

5,36E-09

negative regulation of blood coagulation (GO:0030195)

23,21

3,57E-05

cellular response to sterol (GO:0036315)

22,1

6,23E-05

cornification (GO:0070268)

9,55

4,19E-22

negative regulation of coagulation (GO:0050819)

21,87

4,45E-05

cellular response to low-density lipoprotein particle stimulus (GO:0071404)

20,88

7,55E-05

intermediate filament cytoskeleton organization (GO:0045104)

6,15

1,71E-05

positive regulation of blood vessel diameter (GO:0097755)

20,68

5,47E-05

nitric oxide mediated signal transduction (GO:0007263)

19,78

9,07E-05

intermediate filament-based process (GO:0045103)

6,02

2,01E-05

alpha-amino acid catabolic process (GO:1901606)

14,22

3,39E-05

low-density lipoprotein particle clearance (GO:0034383)

19,57

1,20E-05

multicellular organismal water homeostasis (GO:0050891)

5,96

1,29E-06

cellular amino acid catabolic process (GO:0009063)

11,95

7,50E-05

cholesterol biosynthetic process (GO:0006695)

17,89

4,91E-08

water homeostasis (GO:0030104)

5,95

5,17E-07

positive regulation of vasculature development (GO:1904018)

11

4,31E-06

secondary alcohol biosynthetic process (GO:1902653)

17,48

5,77E-08

keratinization (GO:0031424)

5,14

1,29E-15

negative regulation of cell activation (GO:0050866)

9,43

5,00E-05

regulation of cholesterol biosynthetic process (GO:0045540)

17,48

5,77E-08

peptide cross-linking (GO:0018149)

4,9

9,40E-05

regulation of vasculature development (GO:1901342)

7,29

1,61E-05

regulation of sterol biosynthetic process (GO:0106118)

17,48

5,77E-08

skin development (GO:0043588)

4,7

1,78E-21

regulation of angiogenesis (GO:0045765)

7,03

7,03E-05

isoprenoid biosynthetic process (GO:0008299)

16,2

2,69E-05

regulation of epidermis development (GO:0045682)

4,64

1,46E-05

regulation of small molecule metabolic process (GO:0062012)

6,44

3,81E-05

sterol biosynthetic process (GO:0016126)

15,66

1,23E-07

keratinocyte differentiation (GO:0030216)

4,64

2,76E-15

small molecule biosynthetic process (GO:0044283)

5,78

1,13E-06

plasma lipoprotein particle clearance (GO:0034381)

14,09

8,41E-06

epidermal cell differentiation (GO:0009913)

4,37

1,05E-15

negative regulation of cell proliferation (GO:0008285)

5,05

4,49E-06

regulation of cholesterol metabolic process (GO:0090181)

13,42

3,56E-07

regulation of sodium ion transport (GO:0002028)

4,32

2,87E-05

regulation of cell migration (GO:0030334)

4,54

5,33E-06

interferon-gamma-mediated signaling pathway (GO:0060333)

13,23

1,34E-08

cell-cell junction organization (GO:0045216)

4,07

9,97E-07

regulation of cell motility (GO:2000145)

4,25

1,08E-05

regulation of alcohol biosynthetic process (GO:1902930)

12,87

1,71E-08

epidermis development (GO:0008544)

4,02

2,52E-17

regulation of locomotion (GO:0040012)

3,91

2,57E-05

regulation of steroid biosynthetic process (GO:0050810)

12,45

4,44E-09

cellular response to decreased oxygen levels (GO:0036294)

3,83

1,22E-06

regulation of cellular component movement (GO:0051270)

3,89

2,72E-05

regulation of plasma lipoprotein particle levels (GO:0097006)

11,74

1,84E-07

negative regulation of immune effector process (GO:0002698)

3,74

3,32E-05

secretion by cell (GO:0032940)

3,78

3,62E-05

regulation of steroid metabolic process (GO:0019218)

11,74

6,70E-11

cellular response to hypoxia (GO:0071456)

3,66

7,17E-06

regulation of immune response (GO:0050776)

3,52

7,42E-05

cholesterol transport (GO:0030301)

11,74

4,39E-06

cellular response to oxygen levels (GO:0071453)

3,46

4,92E-06

regulation of immune system process (GO:0002682)

3,12

2,23E-05

cholesterol metabolic process (GO:0008203)

10,9

7,51E-10

cell junction organization (GO:0034330)

3,44

3,69E-07

immune system process (GO:0002376)

2,76

7,14E-07

secondary alcohol metabolic process (GO:1902652)

10,44

1,22E-09

epithelial cell differentiation (GO:0030855)

3,16

1,17E-16

regulation of developmental process (GO:0050793)

2,53

2,87E-05

sterol transport (GO:0015918)

9,96

1,18E-05

regulation of autophagy (GO:0010506)

3,11

7,36E-08

regulation of response to stimulus (GO:0048583)

2,02

5,62E-05

cholesterol homeostasis (GO:0042632)

9,76

3,21E-06

protein autophosphorylation (GO:0046777)

3,05

4,19E-05

  1. GO annotation raw p value <0.0001
  2. List of 25 GO categories statistically overrepresented for overexpressed genes at each time point analyzed (day 4, 10 and 22) after comparing Azm treatment to non-treated ALI cultures