Fig. 5
From: Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia
Formation of epidermal barrier – Azm induced lamellar body formation. a. VA10 cells differentiated on 0.4 μm filters in ALI cultures treated with Azm (Panel far right) showed a marked increase in MVB formation. LB formations were identified in the cells but not present in the control cells (panel far left). Images show different magnifications. Scale bars are 10.0 μm for top images, 2.0 μm for middle images and 1.0 μm for bottom images. b. Simplified illustration of LB formation based on Brasch et al. 2004 [38]. c. LAMP1 protein expression is increased in Azm treated cells while Pro-SFPB expression is unchanged. LAMP1 quantification is seen on the right