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Fig. 5 | Respiratory Research

Fig. 5

From: Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis

Fig. 5

Expression of hypoxia-inducible alpha subunits in normal and diseased lung tissue. HIF-1α and HIF-2α expression are more evident in fibroblasts from idiopathic pulmonary fibrosis (a, d) than from lung tissue affected by other inflammatory conditions (i.e. chronic bronchitis, panels b and e) or normal lung tissue (c, f); as demonstrated by a higher proportion of positive fibroblasts (open arrows) than negative ones (solid black arrows). For HIF-3α expression there are no significant differences in fibroblasts but in the alveolar wall, the latter shows a positive IHC reaction in different cellular elements in controls (i) and hypersensitivity pneumonitis (h), while no expression in idiopathic pulmonary fibrosis (g)

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