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Table 5 The skin viscoelastic modulus is associated with blood biomarkers of inflammation and tissue metalloprotease activity

From: Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers

  Bivariate Multiple Regression#
  β P-value β P-value
TNFα     
 VE 0.03 0.66 0.18 0.79
 FWS 0.012 0.09 0.002 0.98
TNF R1
 VE −0.14 0.045 −0.11 0.08
 FWS 0.15 0.027 0.16 0.004
TNF R2
 VE −0.17 0.01 −0.14 0.02
 FWS 0.136 0.049 0.15 0.02
CRP
 VE −0.15 0.03 −0.13 0.01
 FWS 0.04 0.56 0.04 0.49
PTX3
 VE 0.21 0.002 0.16 0.051
 FWS 0.03 0.63 0.03 0.76
SAA
 VE −0.16 0.017 −0.15 <0.0001
 FWS 0.08 0.25 0.08 0.20
MMP1
 VE − 0.16 0.02 −0.13 0.03
 FWS 0.04 0.59 0.05 0.43
MMP7
 VE −0.09 0.19 −0.08 0.27
 FWS 0.11 0.11 0.11 0.08
TIMP1
 VE −0.14 0.04 −0.12 0.08
 FWS 0.04 0.59 0.04 0.54
TIMP2
 VE −0.20 0.003* −0.19 0.01
 FWS 0.09 0.18 0.11 0.16
TIMP4
 VE −0.22 0.0015* −0.20 <0.0001
 FWS 0.09 0.20 0.09 0.21
  1. Notes: Bivariate and multiple regression analyses were performed to evaluate the relationship between plasma biomarkers of inflammation and tissue metalloprotease activity with skin viscoelasticity (VE) and facial wrinkling (FWS)
  2. TNFα, tumor necrosis factor α; TNFR, tumor necrosis factor receptor; CRP, C reactive protein; PTX3, pentraxin 3; SAA, serum amyloid A; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase
  3. *Significant (P<0.05) after correction for multiple comparison testing (Holm-Šídák method). #Adjusted for current smoking, pack year smoking history, and the degree of airflow obstruction