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Table 5 The skin viscoelastic modulus is associated with blood biomarkers of inflammation and tissue metalloprotease activity

From: Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers

 

Bivariate

Multiple Regression#

 

β

P-value

β

P-value

TNFα

    

 VE

0.03

0.66

0.18

0.79

 FWS

0.012

0.09

0.002

0.98

TNF R1

 VE

−0.14

0.045

−0.11

0.08

 FWS

0.15

0.027

0.16

0.004

TNF R2

 VE

−0.17

0.01

−0.14

0.02

 FWS

0.136

0.049

0.15

0.02

CRP

 VE

−0.15

0.03

−0.13

0.01

 FWS

0.04

0.56

0.04

0.49

PTX3

 VE

0.21

0.002

0.16

0.051

 FWS

0.03

0.63

0.03

0.76

SAA

 VE

−0.16

0.017

−0.15

<0.0001

 FWS

0.08

0.25

0.08

0.20

MMP1

 VE

− 0.16

0.02

−0.13

0.03

 FWS

0.04

0.59

0.05

0.43

MMP7

 VE

−0.09

0.19

−0.08

0.27

 FWS

0.11

0.11

0.11

0.08

TIMP1

 VE

−0.14

0.04

−0.12

0.08

 FWS

0.04

0.59

0.04

0.54

TIMP2

 VE

−0.20

0.003*

−0.19

0.01

 FWS

0.09

0.18

0.11

0.16

TIMP4

 VE

−0.22

0.0015*

−0.20

<0.0001

 FWS

0.09

0.20

0.09

0.21

  1. Notes: Bivariate and multiple regression analyses were performed to evaluate the relationship between plasma biomarkers of inflammation and tissue metalloprotease activity with skin viscoelasticity (VE) and facial wrinkling (FWS)
  2. TNFα, tumor necrosis factor α; TNFR, tumor necrosis factor receptor; CRP, C reactive protein; PTX3, pentraxin 3; SAA, serum amyloid A; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase
  3. *Significant (P<0.05) after correction for multiple comparison testing (Holm-Šídák method). #Adjusted for current smoking, pack year smoking history, and the degree of airflow obstruction
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Respiratory Research

ISSN: 1465-993X

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