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Table 3 The skin viscoelastic modulus is an independent predictor of pulmonary emphysema and airflow obstruction

From: Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers

  Bivariate Multiple Regressiona
  β P-value β P-value
%LAA
 VE −0.23 0.0004 −0.26 0.003
 FWS 0.11 0.09 0.14 0.11
Perc15
 VE 0.17 0.009 0.24 0.001
 FWS − 0.04 0.58 −0.06 0.39
FEV1 (%pred)
 VE 0.09 0.164 0.18 0.013
 FWS −0.02 0.73 −0.07 0.35
FEV1/FVC (%pred)
 VE 0.24 0.0003 0.26 0.001
 FWS −0.11 0.08 −0.13 0.07
DLCO (%pred)
 VE 0.38 <0.0001 0.35 <0.0001
 FWS −0.13 0.04 −0.13 0.038
RV/TLC
 VE −0.28 <0.0001 −0.16 0.03
 FWS 0.01 0.09 0.06 0.35
  1. Notes. DLCO, diffusion capacity for carbon monoxide; FEV1, forced expiratory volume in 1 s; FWS, facial wrinkling score; FVC, forced vital capacity in 1 s; LAA% = low attenuation areas, tissue voxels with Hounsfield Unit attenuation values less than −950; Perc15, cut off value in Hounsfield units below which 15% of all voxels are distributed; RV, residual volume; TLC, total lung capacity; VE; skin viscoelastic modulus
  2. aAdjusted for age, gender, sun exposure, active smoking and pack year smoking history