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Table 1 Subject Characteristics

From: DSP variants may be associated with longitudinal change in quantitative emphysema

 

COPDGene

ECLIPSE

 

NHW

AA

Whites

N

3030

1158

1397

Age (year)

62.42 (8.35)

54.45 (7.09)

62.78 (7.50)

Female

1500 (49.5)

579 (50.0)

489 (35.0)

Pack-years

44.54 (24.28)

37.19 (20.75)

47.70 (27.21)

Former smokers

2161 (71.3)

242 (20.9)

896 (64.1)

BMI (kg/m2)

29.08 (5.84)

29.30 (6.69)

26.64 (5.39)

Spirometry Grade

 PRISm

317 (10.5)

177 (15.4)

NA

 Control

1363 (45.1)

645 (56.3)

146 (10.5)

 GOLD I

314 (10.4)

69 (6.0)

NA

 GOLD II

641 (21.2)

175 (15.3)

533 (38.2)

 GOLD III

312 (10.3)

69 (6.0)

551 (39.4)

 GOLD IV

77 (2.5)

11 (1.0)

167 (12.0)

Annual change in %LAA-950

0.02 (0.71)

0.10 (0.54)

0.59 (2.13)

Annual change in ALD

−0.04 (2.05)

−0.22 (2.27)

−1.27 (3.63)

Follow-up Period (years)

5.51 (0.71)

5.59 (0.89)

2.56 (0.81)

Emphysema case (%LAA-950 > 5%) at baseline

1041 (34.4)

188 (16.2)

1112 (79.6)

  1. Mean (SD) for continuous variable; N (%) for categorical variable; BMI= Body Mass Index; GOLD = Global Initiative for Chronic Obstructive Lung Disease; PRISm = Preserved Ratio Impaired Spirometry (FEV1 < 80% predicted with FEV1/FVC > 0.7); %LAA-950 = percentage of low-attenuation area less than -950 Hounsfield units; ALD = Adjusted lung density, NHW=Non-Hispanic Whites; AA = African Americans; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points