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Table 5 Incidence and severity of bleeding regarding bronchoscopic intervention

From: Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease – a prospective, randomized, multicentre cross-over trial

 

Technique

 

Cryobiopsy (N = 359)

Forceps biopsy (N = 359)

Bleeding severity

None/Mild

Moderate/Severe

None/Mild

Moderate/Severe

p- value

Clinical relevance

Low

High

Low

High

Intervention – no (%)

301 (83.8)

58 (16.2)

344 (95.8)

15 (4.2)

TBCB vs TBFB < 0.001

Probe size

 Cryobiopsy

357

     

  Small: 1.9 mm

211

187

25

  

SC vs. LC: p = 0.006

SC vs. LF: p < 0.001

  Large: 2.4 mm

146

112

33

  

 Forceps

355

    

  Small: 1.8–2.0 mm

169

  

165

4

SF vs. LF: p = 0.12

  Large: 2.2–2.6 mm

186

  

175

11

Localization of biopsy

 Upper lobe

 

48

13

  

p = 1.0

 Lower lobe

 

112

32

  

 Upper lobe

   

49

4

p = 0.27

 Lower lobe

   

109

4

  1. *Clinical relevance of bleeding is categorized as “low” (None, and mild bleeding) and “high” (moderate and severe bleeding) for both biopsy techniques. Absolute number of evaluable patients is listed in the second column. P-values were calculated by 2 tail Fisher’s exact test for independent samples, comparing small cryobiopsy (SC) and large cryobiopsy (LC), small forceps biopsy (SF) and large forceps biopsy (LF) as well as small cryobiopsy (SC) and large forceps biopsy (LF)
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Respiratory Research

ISSN: 1465-993X

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