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Table 4 Incidence and severity of bleeding related to patient characteristics*

From: Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease – a prospective, randomized, multicentre cross-over trial

 

Technique

Cryobiopsy (N = 359)

Forceps biopsy (N = 359)

Bleeding severity

None/Mild

Moderate/Severe

p-value

None/Mild

Moderate/Severe

p-value

Clinical relevance

Low

High

Low

High

all – no (%)

301 (83.8)

58 (16.2)

344 (95.8)

15 (4.2)

 

n

      

Age

349

      

  < 65 yr

160

143

17

0.018

155

5

0.59

  > = 65 yr

189

151

38

180

9

Sex

351

      

 Female

153

121

32

0.026

145

8

0.41

 Male

198

175

23

192

6

Body height

342

      

  = <  170 cm

186

146

40

0.002

175

11

0.043

  > 170 cm

156

142

14

154

2

Smoking

332

      

 Non-smoker

132

109

23

0.52

124

8

0.27

 Ex-smoker

138

118

20

135

3

 Current smoker

62

55

7

59

3

Aspirin

354

      

 Yes

51

38

13

0.067

49

2

1.0

 No

303

258

45

290

13

  1. *Clinical relevance of bleeding is categorized as “low” (none, and mild bleeding) and “high” (moderate and severe bleeding) for both biopsy techniques. Absolute number (n) of evaluable patients are listed in the second column. Data were missing for age in 10 patients (2.8%), sex in 8 patients (2.2%), body height in 17 patients (4.7%), smoking status in 27 patients (7.5%), and for aspirin use in 5 patients (1.4%). P-values were calculated by 2 tail Fisher’s exact test for independent samples focusing on each technique separately