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Table 1 Comparison of the haemodynamic data and RV function in the MCT-induced PAH rats

From: Transection of the cervical sympathetic trunk inhibits the progression of pulmonary arterial hypertension via ERK-1/2 Signalling

 

Control

MCT

MCT + sham

MCT + TCST

HR (beats/min)

408 ± 39

391 ± 24

407 ± 26

421 ± 15

mSAP (mmHg)

108.89 ± 6.88

100.05 ± 7.77

95.08 ± 4.84

108.87 ± 9.30

RVSP (mmHg)

30.85 ± 5.32

46.83 ± 9.53**

48.36 ± 5.44**

35.21 ± 5.59#&

mPAP (mmHg)

17.34 ± 0.88

34.13 ± 1.30**

31.71 ± 2.94**

22.02 ± 4.03#&

RVTD (mm)

3.69 ± 0.25

4.42 ± 0.27**

4.36 ± 0.29**

3.78 ± 0.40#&

PATD (mm)

2.33 ± 0.23

2.43 ± 0.38

2.63 ± 0.26

2.62 ± 0.18

TAPSE (mm)

2.12 ± 0.04

1.34 ± 0.10*

1.41 ± 0.24*

2.00 ± 0.12$

CO (ml/min)

199.15 ± 12.17

185.78 ± 12.88**

178.53 ± 6.75**

204.72 ± 11.13#&

RV/LV + S

0.22 ± 0.08

0.38 ± 0.08**

0.48 ± 0.10**

0.24 ± 0.07#&

  1. All values are expressed as the mean ± SD. CO, cardiac output; HR, heart rate; mPAP, mean pulmonary arterial pressure; RVSP, right ventricular systolic pressure; mSAP, mean systemic arterial pressure; PATD, pulmonary artery transverse diameter; RV/(LV + S), right ventricle/(left ventricle + septum); RVTD, right ventricular transverse diameter; TAPSE, tricuspid annular plane systolic excursion; *P < 0.05 vs. control group; $P < 0.05 vs. MCT or MCT + sham group; **P < 0.01 vs. control group; #P < 0.01 vs. MCT group; &P < 0.01 vs. MCT + sham group