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Fig. 6 | Respiratory Research

Fig. 6

From: Transection of the cervical sympathetic trunk inhibits the progression of pulmonary arterial hypertension via ERK-1/2 Signalling

Fig. 6

Effect of ERK-1/2 on NE-induced proliferation in PASMCs. a PASMC cell proliferation was measured by an EdU staining assay (scale bar = 100 μm). b NE increased the percentage of EdU-positive PASMCs. However, this effect was suppressed by the treatment with Pra or U0126. c NE increased ERK-1/2 phosphorylation in the PASMCs, and this increase was inhibited by Pra and U0126. d, e, f NE increased the expression of PCNA, cyclin A2 and cyclin D1 in the PASMCs, whereas Pra and U0126 attenuated these effects. *P < 0.05 vs. control group; $P < 0.05 vs. NE group

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Respiratory Research

ISSN: 1465-993X

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