Respiratory Research

Table 3 Associations of the 9 bacterial genera and Shannon diversity with pPCs both across all samples and within stable samples in generalized linear mixed models. FDR P-values are indicated in the table. Significant associations are highlighted in asterisks. Only significant variables were included in the final model unless otherwise stated

From: Airway host-microbiome interactions in chronic obstructive pulmonary disease

	Microbiome	Proteome
	Microbiome	pPC1	pPC2	pPC3	pPC4	pPC5	pPC6	pPC7	pPC8
All	Veillonella	0.04*	0.82	0.54	0.62	0.40	0.19	0.62	0.04*
	Prevotella	0.52	0.94	0.01*	0.11	0.02*	0.76	0.01*	0.34
	Haemophilus	0.01*	0.06	1E-3*	0.69	0.25	0.47	0.64	0.56
	Streptococcus	0.29	0.35	0.92	0.69	0.45	0.93	0.13	0.61
	Moraxella	1E-3*	0.54	0.05^a	0.45	0.13	0.40	0.85	0.52
	Megasphaera	0.31	0.36	0.06^a	0.67	0.51	0.01*	1E-4*	0.84
	Neisseria	0.03*	0.06^a	0.22	0.26	0.02*	0.01*	0.02*	0.06
	S24–7	0.67	0.12	0.04*	0.24	0.21	0.58	0.49	0.55
	Selenomonas	2E-3*	0.14	0.58	0.12	0.72	0.69	0.13	0.29
	Shannon	0.04*	0.54	0.78	0.10	0.03*	0.56	0.58	0.09
Stable	Veillonella	0.05^a	0.10	0.10	0.23	0.71	0.47	0.99	0.34
	Prevotella	0.73	0.05^a	0.21	0.03*	0.86	0.38	0.70	0.50
	Haemophilus	0.03*	0.03*	2E-3*	0.08	0.75	0.29	0.73	0.60
	Streptococcus	0.03*	0.93	0.58	0.35	0.76	0.82	0.62	0.24
	Moraxella	0.46	0.97	0.26	0.59	0.95	0.96	0.30	0.79
	Megasphaera	0.38	0.76	0.80	0.69	0.80	0.27	0.67	0.25
	Neisseria	0.23	0.66	0.58	0.70	0.46	0.85	0.55	0.99
	S24–7	0.23	0.83	0.89	0.56	0.95	0.42	0.96	0.21
	Selenomonas	0.75	0.01*	0.65	0.03*	0.07^a	0.70	0.39	0.05*
	Shannon	0.25	0.04*	0.13	0.02*	0.33	0.58	0.77	0.41

^aVariables not statistically significant but present in the model

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