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Table 3 Associations of the 9 bacterial genera and Shannon diversity with pPCs both across all samples and within stable samples in generalized linear mixed models. FDR P-values are indicated in the table. Significant associations are highlighted in asterisks. Only significant variables were included in the final model unless otherwise stated

From: Airway host-microbiome interactions in chronic obstructive pulmonary disease

  Microbiome Proteome
pPC1 pPC2 pPC3 pPC4 pPC5 pPC6 pPC7 pPC8
All Veillonella 0.04* 0.82 0.54 0.62 0.40 0.19 0.62 0.04*
Prevotella 0.52 0.94 0.01* 0.11 0.02* 0.76 0.01* 0.34
Haemophilus 0.01* 0.06 1E-3* 0.69 0.25 0.47 0.64 0.56
Streptococcus 0.29 0.35 0.92 0.69 0.45 0.93 0.13 0.61
Moraxella 1E-3* 0.54 0.05a 0.45 0.13 0.40 0.85 0.52
Megasphaera 0.31 0.36 0.06a 0.67 0.51 0.01* 1E-4* 0.84
Neisseria 0.03* 0.06a 0.22 0.26 0.02* 0.01* 0.02* 0.06
S24–7 0.67 0.12 0.04* 0.24 0.21 0.58 0.49 0.55
Selenomonas 2E-3* 0.14 0.58 0.12 0.72 0.69 0.13 0.29
Shannon 0.04* 0.54 0.78 0.10 0.03* 0.56 0.58 0.09
Stable Veillonella 0.05a 0.10 0.10 0.23 0.71 0.47 0.99 0.34
Prevotella 0.73 0.05a 0.21 0.03* 0.86 0.38 0.70 0.50
Haemophilus 0.03* 0.03* 2E-3* 0.08 0.75 0.29 0.73 0.60
Streptococcus 0.03* 0.93 0.58 0.35 0.76 0.82 0.62 0.24
Moraxella 0.46 0.97 0.26 0.59 0.95 0.96 0.30 0.79
Megasphaera 0.38 0.76 0.80 0.69 0.80 0.27 0.67 0.25
Neisseria 0.23 0.66 0.58 0.70 0.46 0.85 0.55 0.99
S24–7 0.23 0.83 0.89 0.56 0.95 0.42 0.96 0.21
Selenomonas 0.75 0.01* 0.65 0.03* 0.07a 0.70 0.39 0.05*
Shannon 0.25 0.04* 0.13 0.02* 0.33 0.58 0.77 0.41
  1. aVariables not statistically significant but present in the model